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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,494 - 1,499 (6page)
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Purpose: The aim of this study was to investigate whether the peroxisomal proliferator-activated receptor gamma (PPARγ) ligand troglitazone in combination with photodynamic therapy (PDT) enhances the apoptotic response of DLD-1 colon cancer cells.
Materials and Methods: The effects of troglitazone, PDT, and troglitazone in combination with PDT on cell viability and apoptosiswere assessed in DLD-1 cells. Cell viability and proliferation were evaluated using the tetrazolium-based MTT assay, and apoptosis was evaluated via cell staining with propidium iodide (PI) and annexin V-FITC. The levels of pro-caspase-3 were measuredvia Western blot analyses.
Results: Treatment of troglitazone and PDT induced the growth retardation and cell death of DLD-1 cells in a dose-dependent manner, respectively. The combination treatment significantly suppressed cell growth and increased the apoptotic response of DLD-1 and resulted in apoptosis rather than necrosis, as shown by PI/annexin V staining and degradation of procaspase-3.
Conclusion: These results document the anti-proliferative and apoptotic activities of PDT in combination with the PPARγ ligand troglitazone and provide a strong rationale for testing the therapeutic potential of combination treatment in colon cancer.
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참고문헌 (33)
참고문헌 신청
Dougherty TJ / 1998 / Photodynamic therapy / J Natl Cancer Inst 90:889~905
Krosl G / 1996 / Potentiation of photodynamic therapy-elicited antitumor response by localized treatment with granulocyte-macrophage colony-stimulating factor / Cancer Res 56:3281~3286
Kim HR / 1999 / Enhanced apoptotic response to photodynamic therapy after bcl-2 transfection / Cancer Res 59:3429~3432
Usuda J / 2001 / Increased cytotoxic effects of photodynamic therapy in IL-6gene transfected cells via enhanced apoptosis / Int J Cancer 93:475~480
Vanden Heuvel JP / 1999 / Peroxisome proliferator-activated receptors: a critical link among fatty acids, gene expression and carcinogenesis / J Nutr 129(2S Suppl):575S~580S
Krosl G / 1996 / Potentiation of photodynamic therapy-elicited antitumor response by localized treatment with granulocyte-macrophage colony-stimulating factor / Cancer Res 56:3281~3286
Kim HR / 1999 / Enhanced apoptotic response to photodynamic therapy after bcl-2 transfection / Cancer Res 59:3429~3432
Usuda J / 2001 / Increased cytotoxic effects of photodynamic therapy in IL-6gene transfected cells via enhanced apoptosis / Int J Cancer 93:475~480
Vanden Heuvel JP / 1999 / Peroxisome proliferator-activated receptors: a critical link among fatty acids, gene expression and carcinogenesis / J Nutr 129(2S Suppl):575S~580S
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