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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,347 - 1,353 (7page)
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초록· 키워드
오류제보하기
Purpose: Soluble ST2 (sST2) is an emerging prognostic biomarker in patients with cardiovascular disease (CVD). A recent study showed that sST2 predicted incident hypertension. High sensitive C-reactive protein (hsCRP) has been a widely-used biomarker for risk-stratifying in CVD. We compared the abilities of sST2 and hsCRP to predict high risk coronary artery calcium score (CACS).
Materials and Methods: The CACS was assessed by cardiac computed tomography, and sST2 was measured in 456 subjects enrolledin the Mapo-gu community cohort. In accordance with the 2013 ACC/AHA guidelines, we defined the high risk CACS group as individuals with a CACS ≥300 Agatston units (AU).
Results: There were 99 (21.7%) subjects with a CACS ≥300 AU. There was a strong correlation between log sST2 and log hsCRP (r=0.128, p=0.006), and both log sST2 and log hsCRP showed significant associations with CACS (r=0.101, p=0.031 for sST2, r= 0.101, p=0.032 for hsCRP). In net reclassification improvement (NRI) analysis, the NRI for hsCRP over sST2 was significant [continuousNRI 0.238, 95% confidence interval (CI) 0.001–0.474, integrated discrimination index (IDI) 0.022, p=0.035], while the NRI for sST2 over hsCRP was not significant (continuous NRI 0.212, 95% CI -0.255–0.453, IDI 0.002, p=0.269).
Conclusion: sST2 does not improve net reclassification for predicting a high risk CACS. Using hsCRP provides superior discriminationand risk reclassification for coronary atherosclerosis, compared with sST2.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Budoff MJ / 2007 / Long-term prognosis associated with coronary calcification:observations from a registry of 25,253 patients / J Am Coll Cardiol 49:1860~1870
Detrano R / 2008 / Coronary calcium as a predictor of coronary events in four racial or ethnic groups / N Engl J Med 358:1336~1345
Goff DC Jr / 2014 / 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines / Circulation 129(25 Suppl 2):S49~S73
Januzzi JL Jr / 2013 / ST2 as a cardiovascular risk biomarker: from the bench to the bedside / J Cardiovasc Transl Res 6:493~500
van Kimmenade RR / 2012 / Emerging biomarkers in heart failure / Clin Chem 58:127~138
Detrano R / 2008 / Coronary calcium as a predictor of coronary events in four racial or ethnic groups / N Engl J Med 358:1336~1345
Goff DC Jr / 2014 / 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines / Circulation 129(25 Suppl 2):S49~S73
Januzzi JL Jr / 2013 / ST2 as a cardiovascular risk biomarker: from the bench to the bedside / J Cardiovasc Transl Res 6:493~500
van Kimmenade RR / 2012 / Emerging biomarkers in heart failure / Clin Chem 58:127~138
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