지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 428 - 434 (7page)
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Purpose: To analyze the correlation of polymorphisms of toll-like receptor 7 (TLR7) (rs179009) and toll-like receptor 9 (TLR9) (rs187084) in hepatitis C virus (HCV) infections in the Han population. Materials and Methods: The genotypes of TLR7IVS2-151 in HCV infection were detected by Sanger sequencing using polymerase chain reaction-restriction fragment length polymorphism to determine the TLR9 T-1486C single nucleotide polymorphisms (SNP) for all enrolled patients. Results: We found no significant difference between males with spontaneousclearance of HCV versus those chronically infected [χ²=2.71, p=0.10, odd ratios(OR)=0.58, 95% confidence interval (CI) 0.31-1.11]. However, significant differences were found for the distribution of TLR7 (rs179009) in females (χ²=9.46, p=0.01). In females, a significant difference was also found between chronic hepatitis C and those with spontaneous clearance of HCV in terms of TLR7 IVS2-151G/A allele frequencies (χ²=9.50, p=0.00, OR=0.46, 95% CI 0.28-0.75). In HCV-infected patients, no significant association was found between the frequency of TLR9 genotypes and alleles. Conclusion: The site of TLR7 IVS2-151 (rs179009) G/A may be a factor for susceptibility of chronic HCV in the femaleHan population. TLR9T-1486C (rs18084) SNP may not play a major role in HCV infection. However, individual risk profiles for HCV infection did vary by sex and this relationship should be further investigated.
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참고문헌 (27)
참고문헌 신청
Akira S / 2006 / Pathogen recognition and innate immunity / Cell 124 : 783 ~ 801
Arpaia N / 2011 / Toll-like receptors: key players in antiviral immunity / Curr Opin Virol 1 : 447 ~ 454
Askar E / 2010 / Toll-like receptor 7 rs179008/Gln11Leu gene variants in chronic hepatitis C virus infection / J Med Virol 82 : 1859 ~ 1868
Broering R / 2008 / Toll-like receptor-stimulated non-parenchymal liver cells can regulate hepatitis C virus replication / J Hepatol 48 : 914 ~ 922
Chang S / 2010 / Impaired expression and function of toll-like receptor 7 in hepatitis C virus infection in human hepatoma cells / Hepatology 51 : 35 ~ 42
Arpaia N / 2011 / Toll-like receptors: key players in antiviral immunity / Curr Opin Virol 1 : 447 ~ 454
Askar E / 2010 / Toll-like receptor 7 rs179008/Gln11Leu gene variants in chronic hepatitis C virus infection / J Med Virol 82 : 1859 ~ 1868
Broering R / 2008 / Toll-like receptor-stimulated non-parenchymal liver cells can regulate hepatitis C virus replication / J Hepatol 48 : 914 ~ 922
Chang S / 2010 / Impaired expression and function of toll-like receptor 7 in hepatitis C virus infection in human hepatoma cells / Hepatology 51 : 35 ~ 42
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