지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 276 - 281 (6page)
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초록· 키워드
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Purpose: Procalcitonin (PCT) is a current, frequently used marker for severe bacterial infection. The aim of this study was to assess the ability of PCT levels to differentiate bacteremic from nonbacteremic patients with fever. We assessed whether PCT level could be used to accurately rule out a diagnosis of bacteremia. Materials and Methods: Serum samples and blood culture were obtained from patients with fever between August 2008 and April 2009. PCT was analyzed using a VIDAS^® B.R.A.H.M.S PCT assay. We reviewed the final diagnosis and patient histories, including clinical presentation and antibiotic treatment. Results: A total of 300 patients with fevers were enrolled in this study: 58 with bacteremia (positive blood culture) (group I); 137 with local infection (group II); 90 with other diseases (group III); and 15 with fevers of unknown origin (group IV). PCT levels were significantly higher in patients with bacteremia than in those with non-bacteremia (11.9 ± 25.1 and 2.5 ± 14.7 ng/mL, respectively, p < 0.001). The sensitivity and specificity were 74.2% and 70.1%, respectively, at a cut-off value of 0.5 ng/mL. A serum PCT level of < 0.4 ng/mL accurately rules out diagnosis of bacteremia. Conclusion: In febrile patients, elevated PCT may help predict bacteremia; furthermore, low PCT levels were helpful for ruling out bacteremia as a diagnosis. Therefore, PCT assessment could help physicians limit the number of prescriptions for antibiotics.
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참고문헌 (21)
참고문헌 신청
Assicot M / 1993 / High serum procalcitonin concentrations in patients with sepsis and infection / Lancet 341 : 515 ~ 518
Bates DW / 1997 / Predicting bacteremia in patients with sepsis syndrome. Academic Medical Center Consortium Sepsis Project Working Group / J Infect Dis 176 : 1538 ~ 1551
Becker KL / 2008 / Procalcitonin assay in systemic inflammation, infection, and sepsis: clinical utility and limitations / Crit Care Med 36 : 941 ~ 952
Bossink AW / 1999 / Prediction of microbial infection and mortality in medical patients with fever: plasma procalcitonin, neutrophilic elastase-alpha1-antitrypsin, and lacto
Brunkhorst FM / 2000 / Procalcitonin for early diagnosis and differentiation of SIRS, sepsis, severe sepsis, and septic shock / Intensive Care Med 26 (Suppl 2) : S148 ~ S152
Bates DW / 1997 / Predicting bacteremia in patients with sepsis syndrome. Academic Medical Center Consortium Sepsis Project Working Group / J Infect Dis 176 : 1538 ~ 1551
Becker KL / 2008 / Procalcitonin assay in systemic inflammation, infection, and sepsis: clinical utility and limitations / Crit Care Med 36 : 941 ~ 952
Bossink AW / 1999 / Prediction of microbial infection and mortality in medical patients with fever: plasma procalcitonin, neutrophilic elastase-alpha1-antitrypsin, and lacto
Brunkhorst FM / 2000 / Procalcitonin for early diagnosis and differentiation of SIRS, sepsis, severe sepsis, and septic shock / Intensive Care Med 26 (Suppl 2) : S148 ~ S152
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