지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 942 - 949 (8page)
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초록· 키워드
오류제보하기
Purpose: Endothelial dysfunction (ED) is a pivotal phenomenon in the development of cardiovascular disease (CVD) in patients receiving hemodialysis (HD). Indoxyl sulfate (IS) is a known uremic toxin that induces ED in patients with chronic kidney disease. The aim of this study was to investigate whether AST-120, an absorbent of IS, improves microvascular or macrovascular ED in HD patients.
Materials and Methods: We conducted a prospective, case-controlled trial. Fourteen patients each were enrolled in respective AST-120 and control groups. The subjects in the AST-120 group were treated with AST-120 (6 g/day) for 6 months. Microvascular function was assessed by laser Doppler flowmetry using iontophoresis of acetylcholine (Ach) and sodium nitroprusside (SNP) at baseline and again at 3 and 6 months. Carotid arterial intima-media thickness (cIMT) and flow-mediated vasodilation were measuredat baseline and 6 months. The Wilcoxon rank test was used to compare values before and after AST-120 treatment.
Results: Ach-induced iontophoresis (endothelium-dependent response) was dramatically ameliorated at 3 months and 6 months in the AST-120 group. SNP-induced response showed delayed improvement only at 6 months in the AST-120 group. The IS level was decreased at 3 months in the AST-120 group, but remained stable thereafter. cIMT was significantly reduced after AST-120 treatment. No significant complications in patients taking AST-120 were reported.
Conclusion: AST-120 ameliorated microvascular ED and cIMT in HD patients. A randomized study including a larger population will be required to establish a definitive role of AST-120 as a preventive medication for CVD in HD patients.
목차
등록된 정보가 없습니다.
참고문헌 (41)
참고문헌 신청
Parfrey PS / 1999 / The clinical epidemiology of cardiac disease in chronic renal failure / J Am Soc Nephrol 10:1606~1615
Zimmermann J / 1999 / Inflammation enhances cardiovascular risk and mortality in hemodialysis patients / Kidney Int 55:648~658
Hogas SM / 2010 / Methods and potential biomarkers for the evaluation of endothelial dysfunction in chronic kidney disease: a critical approach / J Am Soc Hypertens 4:116~127
Kolluru GK / 2012 / Endothelial dysfunction and diabetes: effects on angiogenesis, vascular remodeling, and wound healing / Int J Vasc Med 2012:918267
Corrado E / 2008 / Endothelial dysfunction and carotid lesions are strong predictors of clinical events in patients with early stages of atherosclerosis: a 24-month follow-up study / Coron Artery Dis 19:139~144
Zimmermann J / 1999 / Inflammation enhances cardiovascular risk and mortality in hemodialysis patients / Kidney Int 55:648~658
Hogas SM / 2010 / Methods and potential biomarkers for the evaluation of endothelial dysfunction in chronic kidney disease: a critical approach / J Am Soc Hypertens 4:116~127
Kolluru GK / 2012 / Endothelial dysfunction and diabetes: effects on angiogenesis, vascular remodeling, and wound healing / Int J Vasc Med 2012:918267
Corrado E / 2008 / Endothelial dysfunction and carotid lesions are strong predictors of clinical events in patients with early stages of atherosclerosis: a 24-month follow-up study / Coron Artery Dis 19:139~144
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