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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 893 - 899 (7page)
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초록· 키워드
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Purpose: The purpose of this study was to define the role of cyclooxygenase-2 inhibitors (COX-2i) in reducing hepatic fibrosis in pediatric patients with chronic liver disease.
Materials and Methods: From September 2009 to September 2010, patients over 2 years old who visited our outpatient clinic for follow-up to manage their chronic liver disease after Kasai portoenterostomy for biliary atresia, were included in this study. Volunteerswere assigned to the study or control groups, according to their preference. A COX-2i was given to only the study group after obtaining consent. The degree of hepatic fibrosis (liver stiffness score, LSS) was prospectively measured using FibroScan, and liver function was examined using serum analysis before and after treatment. After 1 year, changes in LSSs and liver function were compared between the two groups.
Results: Twenty-five patients (18 females and 7 males) were enrolled in the study group. The control group included 44 patients (26 females and 18 males). After 1 year, the least square mean values for the LSSs were significantly decreased by 3.91±0.98 kPa (p=0.004) only in the study group. Serum total bilirubin did not decrease significantly in either group.
Conclusion: COX-2i treatment improved the LSS in patients with chronic liver disease after Kasai portoenterostomy for biliary atresia.
목차
등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Hadzic´ N / 2003 / Long-term survival following Kasai portoenterostomy:is chronic liver disease inevitable? / J Pediatr Gastroenterol Nutr 37:430~433
Hartley JL / 2009 / Biliary atresia / Lancet 374:1704~1713
Davenport M / 2012 / Biliary atresia: clinical aspects / Semin Pediatr Surg 21:175~184
Hadžic´ N / 2011 / Hepatocellular carcinoma in biliary atresia: King’s College Hospital experience / J Pediatr 159:617~622.e1
Hol L / 2008 / Hepatocellular carcinoma complicating biliary atresia after Kasai portoenterostomy / Eur J Gastroenterol Hepatol 20:227~231
Hartley JL / 2009 / Biliary atresia / Lancet 374:1704~1713
Davenport M / 2012 / Biliary atresia: clinical aspects / Semin Pediatr Surg 21:175~184
Hadžic´ N / 2011 / Hepatocellular carcinoma in biliary atresia: King’s College Hospital experience / J Pediatr 159:617~622.e1
Hol L / 2008 / Hepatocellular carcinoma complicating biliary atresia after Kasai portoenterostomy / Eur J Gastroenterol Hepatol 20:227~231
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