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학술저널
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연세대학교 의과대학 Yonsei Medical Journal Yonsei Medical Journal 제59권 제9호
발행연도
2018.1
수록면
1,115 - 1,122 (8page)

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Purpose: To investigate biomechanical properties of the cornea using a dynamic Scheimpflug analyzer according to age. Materials and Methods: In this prospective, cross-sectional, observational study, participants underwent ophthalmic investigationsincluding corneal biomechanical properties, keratometric values, intraocular pressure (IOP), and manifest refraction sphericalequivalent (MRSE). We determined the relationship of biomechanical parameters and ocular/systemic variables (participant’sage, MRSE, IOP, and mean keratometric values) by piecewise regression analysis, association of biomechanical parameterswith variables by Spearman’s correlation and stepwise multiple regression analyses, and reference intervals (RI) by the bootstrapmethod. Results: This study included 217 eyes of 118 participants (20–81 years of age). Piecewise regression analysis between Corvis-centralcorneal thickness (CCT) and participant’s age revealed that the optimal cut-off value of age was 45 years. No clear breakpointswere detected between the corneal biomechanical parameters and MRSE, IOP, and mean keratometric values. Corneal velocity,deformation amplitude, radius, maximal concave power, Corvis-CCT, and Corvis-IOP exhibited correlations with IOP, regardless ofage (all ages, 20–44 years, and over 44 years). With smaller deformation amplitude and corneal velocity as well as increased Corvis-IOP and Corvis-CCT, IOP became significantly increased. We provided the results of determination of confidence interval from RIdata using bootstrap method in three separate age groups (all ages, 20–44 years, and over 44 years). Conclusion: We demonstrated multiple corneal biomechanical parameters according to age, and reported that the corneal biomechanicalparameters are influenced by IOP.

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