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연세대학교 의과대학 Yonsei Medical Journal Yonsei Medical Journal 제59권 제9호
발행연도
2018.1
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1,015 - 1,025 (11page)

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Kidney diseases including acute kidney injury and chronic kidney disease are among the largest health issues worldwide. Dialysisand kidney transplantation can replace a significant portion of renal function, however these treatments still have limitations. Toovercome these shortcomings, a variety of innovative efforts have been introduced, including cell-based therapies. During thepast decades, advances have been made in the stem cell and developmental biology, and tissue engineering. As part of such efforts,studies on renal cell therapy and artificial kidney developments have been conducted, and multiple therapeutic interventionshave shown promise in the pre-clinical and clinical settings. More recently, therapeutic cell-secreting secretomes have emerged asa potential alternative to cell-based approaches. This approach involves the use of renotropic factors, such as growth factors andcytokines, that are produced by cells and these factors have shown effectiveness in facilitating kidney function recovery. This reviewfocuses on the renotropic functions of bioactive compounds that provide protective and regenerative effects for kidney tissuerepair, based on the available data in the literature.

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