지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1,138 - 1,142 (5page)
이용수
초록· 키워드
오류제보하기
This study aimed to analyze the impact of sleep deprivation (SD) on cardiac, hemodynamic, and endothelial parameters and todetermine whether these are sustained with increased periods of SD. The study included 60 healthy men (mean: age 31.2±6.3years; body mass index 24.6±2.6 kg/m2). Hemodynamic parameters, parameters of myocardial contractility, spectral analysis ofheart rate (HR) and blood pressure (BP) variability, and the sensitivity of arterial baroreflex function were evaluated. Biochemicaltests were performed to assess L-arginine (L-Arg) and asymmetric dimethylarginine (ADMA) levels in reflection of endothelialnitric oxide synthase ability. Measurements of cardiovascular system parameters were obtained at 9 a.m. (baseline) on the firstday of the study and 9 a.m. (24-h SD), 1 p.m. (28-h SD), and 5 p.m. (32-h SD) on the second day. Blood samples for evaluatingbiochemical parameters were obtained at baseline and after 24-h SD. ANOVA Friedman’s test revealed a significant effect fortime in relation to HR (χ2=26.04, df=5, p=0.000), systolic BP (χ2=35.98, df=5, p=0.000), diastolic BP (χ2=18.01, df=5, p=0.003), andmean BP (χ2=28.32, df=5, p=0.000). L-Arg and ADMA levels changed from 78.2±12.9 and 0.3±0.1 at baseline to 68.8±10.2 and0.4±0.1 after 24-hr SD, respectively (p=0.001, p=0.004). SD in healthy men is associated with increases in BP, which appear to occurafter 24 hours of SD and are maintained over increasing periods of SD. The observed hemodynamic changes may have resulteddue to disordered vascular endothelial function, as reflected in alterations in L-Arg and ADMA levels.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Gangwisch JE / 2014 / A review of evidence for the link between sleep duration and hypertension / Am J Hypertens 27:1235~1242
Javaheri S / 2008 / Sleep quality and elevated blood pressure in adolescents / Circulation 118:1034~1040
Verdecchia P / 2007 / Ambulatory blood pressure and cardiovascular outcome in relation to perceived sleep deprivation / Hypertension 49:777~783
Cincin A / 2015 / Effect of acute sleep deprivation on heart rate recovery in healthy young adults / Sleep Breath 19:631~636
Mullington JM / 2009 / Cardiovascular, inflammatory, and metabolic consequences of sleep deprivation / Prog Cardiovasc Dis 51:294~302
Javaheri S / 2008 / Sleep quality and elevated blood pressure in adolescents / Circulation 118:1034~1040
Verdecchia P / 2007 / Ambulatory blood pressure and cardiovascular outcome in relation to perceived sleep deprivation / Hypertension 49:777~783
Cincin A / 2015 / Effect of acute sleep deprivation on heart rate recovery in healthy young adults / Sleep Breath 19:631~636
Mullington JM / 2009 / Cardiovascular, inflammatory, and metabolic consequences of sleep deprivation / Prog Cardiovasc Dis 51:294~302
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