지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 650 - 655 (6page)
이용수
초록· 키워드
오류제보하기
Purpose: Methylphenidate (MPH) is an effective medication for the treatment of attention deficit hyperactivity
disorder (ADHD). However, about 30% of patients do not respond to or are unable to tolerate MPH. Based on
previous findings, we hypothesized that great variability in response time (RT) among Korean children with ADHD
on a computerized continuous performance attention test would be related to poor MPH treatment response.
Materials and Methods: Children (ages 6-18 years) with ADHD were recruited for a prospective 12-week, openlabeled,
multicenter study to examine optimal dosage of OROS methylphenidate. Of the 144 subjects selected, 28
dropped out due to adverse events, medication noncompliance, or follow-up loss, and an additional 26 subjects with
comorbid disorders were excluded from statistical analyses. We defined ‘responders’ as subjects who received a
score of less than 18 on the attention deficit hyperactivity disorder rating scale (ARS; Korean version, K-ARS) and
a score of 1 or 2 on the Clinical Global Impression-Improvement scale (CGI-I). RT variability was assessed with
the ADHD diagnostic system (ADS). Results: Fifty-nine (67%) subjects responded to MPH treatment. The nonresponders
showed greater RT variability at baseline (Mann Whitney U = 577.0, p < 0.01). Baseline RT variability
was a significant predictor of MPH response (Nagelkerke R2 = 0.136, p < 0.01). It predicted 94.9% of responder,
17.2% of non-responder and 69.3% of overall group. Conclusion: High RT variability may predict poor response
to MPH treatment in children with ADHD.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
American Psychiatric Association / 2000 / Diagnostic and Statistical Manual of Mental Disorders. 4th ed / American Psychiatric Association
Barkley RA / 1981 / The use of psychopharmacology to study reciprocal influences in parent-child interaction / J Abnorm Child Psychol 9 : 303 ~ 310
Barkley RA / 1988 / The effects of methylphenidate on the interactions of preschool ADHD children with their mothers / J Am Acad Child Adolesc Psychiatry 27 : 336 ~ 341
Barkley RA / 1989 / Hyperactive girls and boys: stimulant drug effects on mother-child interactions / J Child Psychol Psychiatry 30 : 379 ~ 390
Barkley RA / 2004 / Young adult follow-up of hyperactive children: antisocial activities and drug use / J Child Psychol Psychiatry 45 : 195 ~ 211
Barkley RA / 1981 / The use of psychopharmacology to study reciprocal influences in parent-child interaction / J Abnorm Child Psychol 9 : 303 ~ 310
Barkley RA / 1988 / The effects of methylphenidate on the interactions of preschool ADHD children with their mothers / J Am Acad Child Adolesc Psychiatry 27 : 336 ~ 341
Barkley RA / 1989 / Hyperactive girls and boys: stimulant drug effects on mother-child interactions / J Child Psychol Psychiatry 30 : 379 ~ 390
Barkley RA / 2004 / Young adult follow-up of hyperactive children: antisocial activities and drug use / J Child Psychol Psychiatry 45 : 195 ~ 211
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