지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 625 - 633 (9page)
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Purpose: Pathologic changes in the growth plate remain unknown in Legg-Calvé-Perthes (LCP) disease. Spontaneously hypertensive rats have proven to be a good model for studying LCP disease. This study investigated the histopathologic changes and the expression of vascular endothelial growth factor in the growth plate of spontaneously hypertensive rats (SHR). Materials and Methods: Sixty SHR rats were divided into two groups: those showing osteonecrosis (SHR+n group: 32), and those showing normal ossification (SHR-n group: 28). Thirty Wister Kyoto rats served as a control. For histomorphological measurement, the length of each zone of the growth plate was measured. Cell kinetics was measured by 5-bromo-2’-deoxyuridin (BrdU) immunohistochemistry and transferase-mediated deoxyuridine triphosphate-biotin nick end labeling (TUNEL) assays. Vascular endothelial growth factor (VEGF) immunohistochemistry was used to identify of expression of VEGF. Results: The lengths of growth plates of the SHR+n group were significantly shorter in the initial growth period than those of the other groups. The lowest proliferative rate and the highest apoptosis rate were observed in the SHR+n group at the initial growth period. The expression of VEGF in the growth plate of the SHR group was lower than the control group, and it was lower in the SHR+n group than in the SHR-n group. Conclusion: The growth plate of the SHR+n group was found to be affected by disease process of ischemic necrosis of the femoral head, and this might explain the relative overgrowth of the greater trochanter in the later stages of LCP disease.
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참고문헌 (20)
참고문헌 신청
Farnum CE / 1993 / Determination of proliferative characteristics of growth plate chondrocytes by labeling with bromodeoxyuridine / Calcif Tissue Int 52 : 110 ~ 119
Galotto M / 1994 / Hypertrophic chondrocytes undergo further differentiation to osteoblast-like cells and participate in the initial bone formation in developing chick embry
Gerber HP / 1999 / VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation / Nat Med 5 : 623 ~ 628
Hirano T / 1992 / Osteonecrosis of the femoral head in spontaneously hypertensive rats. Relation to ossific nuclei during growth / Acta Orthop Scand 63 : 37 ~ 40
Hirano T / 1996 / Characteristics of blood vessels feeding the femoral head liable to osteonecrosis in spontaneously hypertensive rats / Calcif Tissue Int 58 : 201 ~ 205
Galotto M / 1994 / Hypertrophic chondrocytes undergo further differentiation to osteoblast-like cells and participate in the initial bone formation in developing chick embry
Gerber HP / 1999 / VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation / Nat Med 5 : 623 ~ 628
Hirano T / 1992 / Osteonecrosis of the femoral head in spontaneously hypertensive rats. Relation to ossific nuclei during growth / Acta Orthop Scand 63 : 37 ~ 40
Hirano T / 1996 / Characteristics of blood vessels feeding the femoral head liable to osteonecrosis in spontaneously hypertensive rats / Calcif Tissue Int 58 : 201 ~ 205
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