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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,572 - 1,581 (10page)
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Purpose: The degradation of the extracellular matrix has been shown to play an important role in the treatment of hepatic cirrhosis.
In this study, the effect of thalidomide on the degradation of extracellular matrix was evaluated in a rat model of hepatic cirrhosis.
Materials and Methods: Cirrhosis was induced in Wistar rats by intraperitoneal injection of carbon tetrachloride (CCl4) three times weekly for 8 weeks. Then CCl4 was discontinued and thalidomide (100 mg/kg) or its vehicle was administered daily by gavagefor 6 weeks. Serum hyaluronic acid, laminin, procollagen type III, and collagen type IV were examined by using a radioimmunoassay.
Matrix metalloproteinase-13 (MMP-13), tissue inhibitor of metalloproteinase-1 (TIMP-1), and α-smooth muscle actin(α-SMA) protein in the liver, transforming growth factor β1 (TGF-β1) protein in cytoplasm by using immunohistochemistry and Western blot analysis, and MMP-13, TIMP-1, and TGF-β1 mRNA levels in the liver were studied using reverse transcriptase polymerase chain reaction.
Results: Liver histopathology was significantly better in rats given thalidomide than in the untreated model group. The levels of TIMP-1 and TGF-β1 mRNA and protein expressions were decreased significantly and MMP-13 mRNA and protein in the liver were significantly elevated in the thalidomide-treated group.
Conclusion: Thalidomide may exert its effects on the regulation of MMP-13 and TIMP-1 via inhibition of the TGF-β1 signaling pathway, which enhances the degradation of extracellular matrix and accelerates the regression of hepatic cirrhosis in rats.
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참고문헌 (37)
참고문헌 신청
Lee UE / 2011 / Mechanisms of hepatic fibrogenesis / Best Pract Res Clin Gastroenterol 25:195~206
Ahmad A / 2012 / Understanding the mechanism of hepatic fibrosis and potential therapeutic approaches / Saudi J Gastroenterol 18:155~167
Inagaki Y / 2012 / Novel anti-fibrotic modalities for liver fibrosis : molecular targeting and regenerative medicine in fibrosis therapy / J Gastroenterol Hepatol ; Suppl 27(Suppl 2):85~88
Enomoto N / 2002 / Thalidomide prevents alcoholic liver injury in rats through suppression of Kupffer cell sensitization and TNF-alpha production / Gastroenterology 123:291~300
Hung KC / 2013 / Effect of thalidomide on the expression of vascular endothelial growth factor in a rat model of liver regeneration / Oncol Lett 5:852~856
Ahmad A / 2012 / Understanding the mechanism of hepatic fibrosis and potential therapeutic approaches / Saudi J Gastroenterol 18:155~167
Inagaki Y / 2012 / Novel anti-fibrotic modalities for liver fibrosis : molecular targeting and regenerative medicine in fibrosis therapy / J Gastroenterol Hepatol ; Suppl 27(Suppl 2):85~88
Enomoto N / 2002 / Thalidomide prevents alcoholic liver injury in rats through suppression of Kupffer cell sensitization and TNF-alpha production / Gastroenterology 123:291~300
Hung KC / 2013 / Effect of thalidomide on the expression of vascular endothelial growth factor in a rat model of liver regeneration / Oncol Lett 5:852~856
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