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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 362 - 369 (8page)
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초록· 키워드
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Purpose: To describe the incidence, clinical courses, and risk factors for mortality of lower respiratory tract diseases (LRDs) caused by common respiratory viruses (CRVs) in stem cell transplantation (SCT) recipients.
Materials and Methods: We retrospectively reviewed the medical records of 1038 patients who received SCT between January 2007 and August 2011 at a single center in Korea.
Results: Seventy-one CRV-LRDs were identified in 67 (6.5%) patients. The human parainfluenza virus (HPIV) was the most commoncausative pathogen of CRV-LRDs at 100 days [cumulative incidence estimate, 23.5%; 95% confidence interval (CI), 3.3–43.7] and 1 year (cumulative incidence estimate, 69.2%; 95% CI, 45.9–92.5) following SCT. The 30-day overall mortality rates due to influenza-LRDs, respiratory syncytial virus-LRDs, HPIV-LRDs, and human rhinovirus-LRDs were 35.7, 25.8, 31.6, and 42.8%, respectively. Co-pathogens in respiratory specimens were detected in 23 (33.8%) patients. The overall mortality at day 30 after CRV-LRD diagnosis was 32.8% (22/67). High-dose steroid usage (p=0.025), a severe state of immunodeficiency (p=0.033), and lymphopenia (p=0.006) were significantly associated with death within 30 days following CRV-LRD diagnosis in a univariate analysis. Multivariate logistic regressionanalysis revealed that high-dose steroid usage [odds ratio (OR), 4.05; 95% CI, 1.12–14.61; p=0.033] and lymphopenia (OR, 6.57; 95% CI, 1.80–24.03; p=0.004) were independent risk factors for mortality within 30 days of CRV-LRDs.
Conclusion: CRV-LRDs among SCT recipients showed substantially high morbidity and mortality rates. Therefore, the implement of an active diagnostic approaches for CRV infections is required for SCT recipients with respiratory symptoms, especially those receivinghigh-dose steroids or with lymphopenia.
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참고문헌 (20)
참고문헌 신청
Avetisyan G / 2009 / Respiratory syncytial virus infection in recipients of allogeneic stem-cell transplantation: a retrospective study of the incidence, clinical features,
Boeckh M / 2008 / The challenge of respiratory virus infections in hematopoietic cell transplant recipients / Br J Haematol 143 : 455 ~ 467
Chemaly RF / 2006 / Respiratory viral infections in adults with hematologic malignancies and human stem cell transplantation recipients: a retrospective study at a major canc
Chemaly RF / 2012 / The characteristics and outcomes of parainfluenza virus infections in 200 patients with leukemia or recipients of hematopoietic stem cell transplantation
Choi SM / 2011 / Differences in clinical outcomes after 2009 influenza A/H1N1and seasonal influenza among hematopoietic cell transplant recipients / Blood 117 : 5050 ~ 5056
Boeckh M / 2008 / The challenge of respiratory virus infections in hematopoietic cell transplant recipients / Br J Haematol 143 : 455 ~ 467
Chemaly RF / 2006 / Respiratory viral infections in adults with hematologic malignancies and human stem cell transplantation recipients: a retrospective study at a major canc
Chemaly RF / 2012 / The characteristics and outcomes of parainfluenza virus infections in 200 patients with leukemia or recipients of hematopoietic stem cell transplantation
Choi SM / 2011 / Differences in clinical outcomes after 2009 influenza A/H1N1and seasonal influenza among hematopoietic cell transplant recipients / Blood 117 : 5050 ~ 5056
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