지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 115 - 132 (18page)
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초록· 키워드
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Objective : Portulacae Herba (PH) can clear away heat, detoxicate, cool down blood heat. The present studywas designed to investigate the effects of PH on ACD induced by 2,4-dinitrochlorobenzene (DNCB) in mice.
Method : In this experiment, the effects of PH on changes in body weights, thicknesses and weights of ear,thicknesses of dorsum skin, degree of symptoms on the dorsum skin, histopathological changes of ear and dorsumskin, spleen weights, TNF-α and IL-10 in serum were observed. And the effects on the proliferation rates ofsplenocytes were also investigated in vitro and in vivo.
Results : 1. PH spread (PHS) group and PH spread plus administered (PHS+Adm) group didn't show anychanges in weight and thickness of ear.
2. But in PHS and PHS+Adm group, thickness of dorsum skin decreased significantly.
3. And PHS and PHS+Adm group showed meaningful effectiveness on ACD symptoms like erythema,desquamation and keratinization.
4. In histopathological observation, hyperplasia and edema of spongy tissues were remarkablydiminished in PHS and PHS+Adm group.
5. And PH reduced the proliferation rates of splenocytes in vivo and vitro study.
Conclusions : PH effectively decreased symptoms of ACD in this study, therefore PH can be one of medicinalingredients to treat ACD.
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참고문헌 (28)
참고문헌 신청
Ahn SG / 2009 / COMMON SKIN DIESEASE / Doctor's book : 173 ~ 190
Feng PC / 1961 / High Concentration of(-)-Noradrenaline in Portulaca oleracea L / Nature 191 : 1108 ~
Han-Na Kim / 2012 / Effect of Lithospermi Radix on Contact Dermatitis Induced by Dinitrofluorobenzene in Mice / Journal of Pharmacopuncture 15 (2) : 7 ~ 10
Jeon JH / 1997 / A Literature study on the external therapy of contact dermatitis / J Orient Med Surge Opthalmol Otolaryngol 10 (1) : 263 ~ 283
Joo JG / 2011 / Anti-inflammatory Effect of Portulacae Herba Water Extract on Lipopolysaccharide-activated RAW 264.7Macrophages / KyungWon Journal of the Institute of Orient
Feng PC / 1961 / High Concentration of(-)-Noradrenaline in Portulaca oleracea L / Nature 191 : 1108 ~
Han-Na Kim / 2012 / Effect of Lithospermi Radix on Contact Dermatitis Induced by Dinitrofluorobenzene in Mice / Journal of Pharmacopuncture 15 (2) : 7 ~ 10
Jeon JH / 1997 / A Literature study on the external therapy of contact dermatitis / J Orient Med Surge Opthalmol Otolaryngol 10 (1) : 263 ~ 283
Joo JG / 2011 / Anti-inflammatory Effect of Portulacae Herba Water Extract on Lipopolysaccharide-activated RAW 264.7Macrophages / KyungWon Journal of the Institute of Orient
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