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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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- 자료유형
- 학술저널
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- 대한치매학회 Dementia and Neurocognitive Disorders(대한치매학회지) Dementia and Neurocognitive Disorders(대한치매학회지) 제13권 제1호
- 발행연도
- 2014.1
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- 1 - 6 (6page)
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Background: The evaluation of behavioral and psychological symptoms (BPS) in ALS is important because its existence may serve as a prognostic factor and suggest a shared pathology with frontotemporal dementia (FTD) in ALS. In this study, we sought to identify the prevalence of the BPS of ALS patients and evaluate its relationship with the clinical profiles and survival of ALS patients. Methods: One hundred sixty-six patients were enrolled in a cross-sectional cohort analysis from September 2008 to February 2012. All patients had sporadic ALS without a genetic mutation and were collected clinical profiles. The t-test and chi-square test were used to assess differences in the clinical characteristics and caregiver-administered neuropsychiatric inventory (CGA-NPI) scores. The Kaplan-Meier method and Cox proportional hazard model were used for the survival analysis. Results: Forty-two patients had clinically significant BPS (42/166, 25.3%). ALS patients with BPS had worse clinical dementia rating (CDR), ALS Functional Rating Scale-Revised (ALSFRS-R) score, and progression rate of disease than those without BPS. Among CGA-NPI subscales, depression, irritability, apathy, and agitation were higher prevalent than the others. There was a trend for ALS patients with BPS having short survival time than those without BPS in the Kaplan-Meier analysis (p=0.006). However, in the Cox proportional hazard model, BPS in ALS patients were not associated with poor survival. Conclusions: These results support the presence of an overlapping spectrum between ALS and FTD and emphasize the importance of neuropsychiatric evaluations in ALS. Although the association between BPS and prognosis are not explained clearly, these results could be used to stratify ALS patients according to neuropsychiatric symptoms and help investigators to evaluate the BPS in ALS patients.
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참고문헌 (23)
참고문헌 신청
Brooks BR / 2000 / El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis / Amyotroph Lateral Scler Other Motor Neuron Disord 1 : 293 ~ 29
Chin J / 2012 / Neurobehavioral dysfunction in patients with subcortical vascular mild cognitive impairment and subcortical vascular dementia / Clin Neuropsychol 26 : 224 ~
Consonni M / 2013 / The cognitive and behavioural profile of amyotrophic lateral sclerosis : application of the consensus criteria / Behav Neurol 27 : 143 ~ 153
Cooper-Knock J / 2014 / The widening spectrum of C9ORF72-related disease; genotype/phenotype correlations and potential modifiers of clinical phenotype / Acta Neuropathol 12
Goldstein LH / 2013 / Changes in cognition and behaviour in amyotrophic lateral sclerosis : nature of impairment and implications for assessment / Lancet Neurol 12 : 368 ~ 38
Chin J / 2012 / Neurobehavioral dysfunction in patients with subcortical vascular mild cognitive impairment and subcortical vascular dementia / Clin Neuropsychol 26 : 224 ~
Consonni M / 2013 / The cognitive and behavioural profile of amyotrophic lateral sclerosis : application of the consensus criteria / Behav Neurol 27 : 143 ~ 153
Cooper-Knock J / 2014 / The widening spectrum of C9ORF72-related disease; genotype/phenotype correlations and potential modifiers of clinical phenotype / Acta Neuropathol 12
Goldstein LH / 2013 / Changes in cognition and behaviour in amyotrophic lateral sclerosis : nature of impairment and implications for assessment / Lancet Neurol 12 : 368 ~ 38
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