지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치매학회 Dementia and Neurocognitive Disorders(대한치매학회지) Dementia and Neurocognitive Disorders(대한치매학회지) 제14권 제4호
- 발행연도
- 2015.1
- 수록면
- 163 - 167 (5page)
이용수
초록· 키워드
오류제보하기
Background and Purpose One of the most common genetic causes of frontotemporal dementia (FTD) is mutation in the progranulin(PGRN) gene. The aim of this study is to assess the early effects of the PGRN mutations on brain volumes by longitudinal voxel based morphometric(VBM) evaluation in asymptomatic mutation carriers.
Methods We recruited 17 asymptomatic members of families with FTD caused by PGRN mutations; 7 mutation carriers (51.0±11.6 yr)and 10 non-carriers (55.2±6.0 yr, p=0.404). The MRI follow-up intervals of carriers and non-carriers were 788.6±103.8 and 922.0±225.1 days(p=0.124) respectively. We performed cross-sectional and longitudinal VBM analysis on both groups.
Results At baseline, the carriers had lower white matter (WM) volumes in left frontal regions (p<0.001, uncorrected), but had no gray matter(GM) volume reduction. The carrier’s global GM (p=0.924) and WM volume (p=0.364) reduction rate were not different from the noncarrier’s.
However, statistical parametric mapping T-maps showed differentially increased GM volume reductions in the bilateral parietal areasof carriers (p<0.001, uncorrected).
Conclusions The findings from this study to examine WM and GM cross-sectional and longitudinal changes in PGRN mutation carrierssuggest that WM atrophic changes could precede both GM changes and symptom onset in FTD. Asymptomatic PGRN mutation carriershave measurably higher rates of regional GM atrophy than non-carriers even in the pre-dementia stages.
목차
등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
Baker M / 2006 / Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17 / Nature 442 : 916 ~ 919
Beck J / 2008 / A distinct clinical, neuropsychological and radiological phenotype is associated with progranulin gene mutations in a large UK series / Brain 131 (Pt 3) : 70
Borroni B / 2008 / Brain magnetic resonance imaging structural changes in a pedigree of asymptomatic progranulin mutation carriers / Rejuvenation Res 11 : 585 ~ 595
Chow TW / 1999 / Inheritance of frontotemporal dementia / Arch Neurol 56 : 817 ~ 822
Cruchaga C / 2009 / Cortical atrophy and language network reorganization associated with a novel progranulin mutation / Cereb Cortex 19 : 1751 ~ 1760
Beck J / 2008 / A distinct clinical, neuropsychological and radiological phenotype is associated with progranulin gene mutations in a large UK series / Brain 131 (Pt 3) : 70
Borroni B / 2008 / Brain magnetic resonance imaging structural changes in a pedigree of asymptomatic progranulin mutation carriers / Rejuvenation Res 11 : 585 ~ 595
Chow TW / 1999 / Inheritance of frontotemporal dementia / Arch Neurol 56 : 817 ~ 822
Cruchaga C / 2009 / Cortical atrophy and language network reorganization associated with a novel progranulin mutation / Cereb Cortex 19 : 1751 ~ 1760
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Transient upregulation of progranulin in the course of neuroinflammation in experimental autoimmune neuritis
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Differences in age at diagnosis of ovarian cancer for each BRCA mutation type in Japan: optimal timing to carry out risk-reducing salpingo-oophorectomy
Journal of Gynecologic Oncology
2022 .07
-
Controversial Issues on Risk Reducing Surgeries and Surveillance Thereafter of the BRCA Mutation Carriers
대한외과학회 학술대회 초록집
2018 .11
-
Investigation of White Matter and Grey Matter Alterations in the Monkey Brain Following Ischemic Stroke Using Diffusion Tensor Imaging
Investigative Magnetic Resonance Imaging
2022 .12
-
[Breast] Characteristics of Germline BRCA1 and BRCA2 Mutation Carriers and Non-Carriers among High-Risk Breast Cancer Patients
대한외과학회 학술대회 초록집
2022 .11
-
Mutation analysis and characterisation of F9 gene in haemophilia- B population of India
Blood Research
2021 .12
-
알츠하이머병에서 APOE e4 유전형과 인지기능, 뇌 부피, 당 대사량 그리고 뇌 아밀로이드 침착과의 연관성
노인정신의학
2023 .04
-
전두측두엽 치매
생물정신의학
2016 .01
-
Novel Germline Mutations of BRCA1 and BRCA2 in Korean Familial Breast Cancer Patients
전남의대학술지
2019 .01
-
Prevalence of PALB2 Germline Mutations in Early-onset and Familial Breast/Ovarian Cancer Patients from Pakistan
Cancer Research and Treatment
2019 .01
-
The Association of Acquired T790M Mutation with Clinical Characteristics after Resistance to First-Line Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in Lung Adenocarcinoma
Cancer Research and Treatment
2018 .01
-
Sex Differences in Attitudes Toward Marriage and Childbearing Based on the Assumption of Being BRCA1/2 Mutation Carriers Among Young People
Journal of Breast Cancer
2022 .06
-
Congenital hypothyroidism due to thyroglobulin deficiency: a case report with a novel mutation in TG gene
Annals of Pediatirc Endocrinology & Metabolism
2019 .01
-
Carrier Frequency of Spinal Muscular Atrophy in a Large-scale Korean Population
Annals of Laboratory Medicine
2020 .01
-
Incidence, Clinical Features, and Prognostic Impact of CALR Exon 9 Mutations in Essential Thrombocythemia and Primary Myelofibrosis: An Experience of a Single Tertiary Hospital in Korea
Annals of Laboratory Medicine
2015 .01
-
Mutation Analysis of IDH1/2 Genes in Unselected De novo Acute Myeloid Leukaemia Patients in India - Identification of A Novel IDH2 Mutation
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Multi-voxel magnetic resonance spectroscopy of cerebral metabolites in healthy dogs at 1.5 Tesla
Journal of Veterinary Science
2016 .06
-
Gynecomastia in adolescent males: current understanding of its etiology, pathophysiology, diagnosis, and treatment
Annals of Pediatirc Endocrinology & Metabolism
2024 .04
-
연령별 대뇌 피질 두께의 성별 차이에 대한 형태학적 분석
의공학회지
2023 .02
-
Types of 23S Ribosomal RNA Point Mutations and Therapeutic Outcomes for Helicobacter pylori
Gut and Liver
2021 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0