지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치매학회 Dementia and Neurocognitive Disorders(대한치매학회지) Dementia and Neurocognitive Disorders(대한치매학회지) 제15권 제2호
- 발행연도
- 2016.1
- 수록면
- 43 - 48 (6page)
이용수
초록· 키워드
오류제보하기
Background and PurposeAlthough the treatment efficacy of memantine in Parkinson’s disease dementia (PDD) has been reported after several weeks of administration, the long-term effects on brain perfusion and clinical symptoms remain unclear. The current study aimed to follow-up PDD patients after 18 months of memantine treatment using 99mTc hexamethylpropylene amine oxime single photon emission computed tomography (SPECT).
MethodsA total of 15 patients with PDD and 11 healthy participants were recruited into this study and they were assessed with brain SPECT, Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR), Global Deterioration Scale (GDS), and Neuropsychiatric Inventory (NPI). Differences in regional cerebral blood flow (rCBF) between the two groups were evaluated at baseline. After 18 months of memantine administration, changes in brain perfusion, severity of dementia, cognition, and neuropsychiatric disturbances were examined in the patients with PDD.
ResultsThe PDD group showed hypoperfusion in most of the cortical, subcortical, and cerebellar areas compared to healthy controls at baseline. At the follow-up, changes in rCBF, CDR (p=0.32), sum of box of CDR (p=0.49), MMSE (p=0.61), GDS (p=0.79), and NPI (p=0.23) were not significant in the PDD patients.
ConclusionsOur findings implicate that memantine may delay the progression of brain perfusion deficits and clinical symptoms of PDD in the long term.
목차
등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Docherty MJ / 2010 / Parkinson’s disease dementia / Curr Neurol Neurosci Rep 10:292~298
Aarsland D / 2001 / Risk of dementia in Parkinson’s disease : a communitybased, prospective study / Neurology 56:730~736
Schrag A / 2000 / How does Parkinson’s disease affect quality of life? A comparison with quality of life in the general population / Mov Disord 15:1112~1118
Schrag A / 2006 / Caregiverburden in parkinson’s disease is closely associated with psychiatric symptoms, falls, and disability / Parkinsonism Relat Disord 12:35~41
Aarsland D / 2007 / Neuropsychiatric symptoms in patients with Parkinson’s disease and dementia : frequency, profile and associated care giver stress / J Neurol Neurosurg Psychiatry 78:36~42
Aarsland D / 2001 / Risk of dementia in Parkinson’s disease : a communitybased, prospective study / Neurology 56:730~736
Schrag A / 2000 / How does Parkinson’s disease affect quality of life? A comparison with quality of life in the general population / Mov Disord 15:1112~1118
Schrag A / 2006 / Caregiverburden in parkinson’s disease is closely associated with psychiatric symptoms, falls, and disability / Parkinsonism Relat Disord 12:35~41
Aarsland D / 2007 / Neuropsychiatric symptoms in patients with Parkinson’s disease and dementia : frequency, profile and associated care giver stress / J Neurol Neurosurg Psychiatry 78:36~42
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Cerebral Perfusion Changes after Acetyl-L-Carnitine Treatment in Early Alzheimer’s Disease Using Single Photon Emission Computed Tomography
Dementia and Neurocognitive Disorders(대한치매학회지)
2017 .01
-
파킨슨병 치매와 루이소체 치매 환자에서 인지기능과 보호자 부담의 차이점
노인정신의학
2020 .01
-
An Autopsy-Proven Case of Lewy Body Disease Presenting with Severe Dysphagia
Journal Of Movement Disorders
2021 .09
-
Hyperglycemia-Induced Aphasia Presenting with Seizure-like Brain Perfusion Findings on Single Photon Emission Computed Tomography
Dementia and Neurocognitive Disorders(대한치매학회지)
2019 .01
-
Visual Hallucinations and Amyloid Deposition in Parkinson’s Disease Dementia: A Case Report
PSYCHIATRY INVESTIGATION
2016 .01
-
알츠하이머 치매 환자에서 치료 전 중증도에 따른 약물의 장기 치료 효과
생물치료정신의학
2021 .02
-
Associations between Brain Perfusion and Sleep Disturbance in Patients with Alzheimer’s Disease
Dementia and Neurocognitive Disorders(대한치매학회지)
2017 .01
-
치매 환자를 위한 청각 검사의 체계적 문헌 고찰 및 메타 분석
대한이비인후-두경부외과학회지
2021 .01
-
The Effect of Brain-computer Interface-based Cognitive Training in Patients with Dementia
대한물리의학회지
2018 .01
-
Clinical Dementia Rating Orientation Score as an Excellent Predictor of the Progression to Alzheimer’s Disease in Mild Cognitive Impairment
PSYCHIATRY INVESTIGATION
2017 .07
-
Dementia-Free Survival and Risk Factors for Dementia in a Hospital-Based Korean Parkinson’s Disease Cohort
Journal of Clinical Neurology
2017 .01
-
The Factors Associated With the Successful Outcomes of Percutaneous Disc Decompression in Patients With Lumbar Herniated Nucleus Pulposus
Annals of Rehabilitation Medicine
2015 .01
-
The Effect of Cognitive Training in a Day Care Center in Patients with Early Alzheimer’s Disease Dementia: A Retrospective Study
PSYCHIATRY INVESTIGATION
2020 .01
-
Changes in Regional Cerebral Perfusion after Nicergoline Treatment in Early Alzheimer’s Disease: A Pilot Study
Dementia and Neurocognitive Disorders(대한치매학회지)
2017 .01
-
파킨슨병과 치매 환자의 치과치료시 고려사항: 문헌고찰
대한통합치과학회지
2024 .01
-
Safety and Efficacy of Anti-dementia Agents in the Extremely Elderly Patients with Dementia
Journal of Korean Medical Science
2018 .01
-
The Impact of the COVID-19 Pandemic and Social Distancing on Cognition of Alzheimer’s Disease Patients
PSYCHIATRY INVESTIGATION
2022 .11
-
농촌형 치매 안심마을 사업이 지역주민의 치매 인식도, 인지기능, 우울감에 미치는 영향 : 예비연구
노인정신의학
2018 .01
-
Single Photon Emission Computerized Tomography and Neuropsychological Tests That Predict a Good Response to Donepezil Therapy for Alzheimer’s Disease
Dementia and Neurocognitive Disorders(대한치매학회지)
2015 .01
-
Effect of Dietary Habits on Alzheimer’s Disease Progression
Yonsei Medical Journal
2024 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0