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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치매학회 Dementia and Neurocognitive Disorders(대한치매학회지) Dementia and Neurocognitive Disorders(대한치매학회지) 제17권 제2호
- 발행연도
- 2018.1
- 수록면
- 57 - 65 (9page)
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초록· 키워드
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Background and Purpose: Cognitive and gait disturbance are common symptoms in Parkinson's disease (PD). Although the relationship between cognitive impairment and gait dysfunction in PD has been suggested, specific gait patterns according to cognition are not fully demonstrated yet. Therefore, the aim of this study was to investigate gait patterns in PD patients with or without cognitive impairment. Methods: We studied 86 patients at an average of 4.8 years after diagnosis of PD. Cognitive impairment was defined as scoring 1.5 standard deviation below age- and education-specific means on the Korean version of the Mini-Mental State Examination (K-MMSE). Threedimensional gait analysis was conducted for all patients and quantified gait parameters of temporal-spatial data were used. Relationships among cognition, demographic characteristics, clinical features, and gait pattern were evaluated. Results: Cognitive impairment was observed in 41 (47.7%) patients. Compared to patients without cognitive impairment, patients with cognitive impairment displayed reduced gait speed, step length, and stride length. Among K-MMSE subcategories, “registration,” “attention/calculation,” and “visuospatial function” were significantly associated with speed, step length, and stride length. However, age, disease duration, Hoehn-Yahr (HY) stage, or Unified Parkinson's Disease Rating Scale (UPDRS) motor score was not significantly related to any gait analysis parameter. Conclusions: Our present study shows that cognitive impairment is associated with slow and short-stepped gait regardless of HY stage or UPDRS motor score, suggesting that cognitive impairment may serve as a surrogate marker of gait disturbance or fall in PD patients.
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참고문헌 (38)
참고문헌 신청
Morris ME / 1994 / The pathogenesis of gait hypokinesia in Parkinson's disease / Brain 117:1169~1181
Blin O / 1990 / Quantitative analysis of gait in Parkinson patients: increased variability of stride length / J Neurol Sci 98:91~97
Allen NE / 2013 / Recurrent falls in Parkinson's disease: a systematic review / Parkinsons Dis 2013:906274
Amboni M / 2013 / Cognitive contributions to gait and falls: evidence and implications / Mov Disord 28:1520~1533
van Iersel MB / 2004 / Systematic review of quantitative clinical gait analysis in patients with dementia / Z Gerontol Geriatr 37:27~32
Blin O / 1990 / Quantitative analysis of gait in Parkinson patients: increased variability of stride length / J Neurol Sci 98:91~97
Allen NE / 2013 / Recurrent falls in Parkinson's disease: a systematic review / Parkinsons Dis 2013:906274
Amboni M / 2013 / Cognitive contributions to gait and falls: evidence and implications / Mov Disord 28:1520~1533
van Iersel MB / 2004 / Systematic review of quantitative clinical gait analysis in patients with dementia / Z Gerontol Geriatr 37:27~32
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