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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Objectives: Fluoride is widely used in the prevention and control of dental caries. The purpose of this study is to examine the biological effects of Sodium fluoride on the proliferation of oral normal cell in vitro(MDPC-23, HaCaT, HGF-1 cells).
Methods: The proliferation of normal cells and the cyto-skeletal change of normal cells were assessed by WST-1 assay and F-actin stain assay. The statistical significances of the resulting data were analyzed using SPSS(Window 12.0).
Results: The sodium fluoride(0-12 mM) treatment decreased the cell viability in a dose and time dependent manner: HaCaT(6 h): 100±0, 98±0.39, 82±2.68, 75±0.83, 69±1, 67±1.42%(p<0.005); HaCaT(24 h): 100±0, 98±1.85, 54±0.64, 43±0.4, 38±0.32, 36±0.13%(p<0.006), MDPC-23(6 h): 100±0, 93±1.48, 85±0.28, 82±1.58, 79±1.48, 76±1.93%(p<0.009); MDPC-23(24 h): 100±0, 91±1.26, 58±0.65, 49±1, 44±0.74, 2±0.05%(p<0.005), HGF-1(6 h): 100±0, 97±2.93, 89±5, 71±5.42, 58±4.82, 43±3.47%(p<0.009); HGF-1(24 h): 100±0, 97±2.05, 73±1.73, 22±1.61, 14±1.73, 7±0.85%(p<0.005). Thus, changes in cell morphology and disruption of filamentous(F)-actin organization were observed in higher concentration.
Conclusions: These results suggest that higher concentrations of fluoride lead to a reduce the number of cells and morphology change of normal cell.
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참고문헌 (23)
참고문헌 신청
Pihlstrom BL / 2005 / Periodontal diseases / Lancet 366:1809~1820
이숙희 / 2008 / 불소 바니쉬와 클로르헥시딘 바니쉬의 항우식 효과 / 대한소아치과학회지 35(1):83~91
Chesters R K / 1992 / Effect of oral care habits on caries in adoles\-cents / Caries Res 26:299~304
송주현 / 2008 / QLF를 이용한 항우식 제품의 인공우식 재광화 효과에 대한 연구 / 대한소아치과학회지 35(2):287~296
Whitford, G.M / 1990 / The physiological and toxicological characteristics of fluoride / J Dent Res 69:539~549
이숙희 / 2008 / 불소 바니쉬와 클로르헥시딘 바니쉬의 항우식 효과 / 대한소아치과학회지 35(1):83~91
Chesters R K / 1992 / Effect of oral care habits on caries in adoles\-cents / Caries Res 26:299~304
송주현 / 2008 / QLF를 이용한 항우식 제품의 인공우식 재광화 효과에 대한 연구 / 대한소아치과학회지 35(2):287~296
Whitford, G.M / 1990 / The physiological and toxicological characteristics of fluoride / J Dent Res 69:539~549
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