지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 53 - 58 (6page)
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Background: The autophagy is the major route for lysosomal degradation of misfolded protein aggregates and oxidative cell components. We hypothesized that rapamycin (autophagy enhancer) would prolong the survival of motor neuron and suppress the disease progression in amyotrophic lateral sclerosis (ALS). Methods: A total of 24 transgenic mice harboring the human G93A mutated SOD1 gene were used. The clinical status involving rotarod test and survival, and biochemical study of ALS mice model were evaluated. Results: The onset of symptoms was significantly delayed in the rapamycin administration group compared with the control group. However, after the clinical symptom developed, the rapamycin exacerbated the disease progression and shortened the survival of ALS mice model, and apoptosis signals were up-regulated compared with control group. Conclusions: Even though further detailed studies on the relevancy between autophagy and ALS will be needed, our results revealed that the rapamycin administration was not effective for being novel promising therapeutic strategy in ALS transgenic mice and exacerbated the apoptosis.
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참고문헌 (17)
참고문헌 신청
Erlich S / 2007 / Rapamycin is a neuroprotective treatment for traumatic brain injury / Neurobiol Dis 26 : 86 ~ 93
Fornai F / 2008 / Autophagy and amyotrophic lateral sclerosis: The multiple roles of lithium / Autophagy 4 : 527 ~ 530
Fornai F / 2008 / Lithium delays progression of amyotrophic lateral sclerosis / Proc Natl Acad Sci USA 105 : 2052 ~ 2057
Harrison DE / 2009 / Rapamycin fed late in life extends lifespan in genetically heterogeneous mice / Nature 460 : 392 ~ 395
Koh SH / 007 / Inhibition of glycogen synthase kinase-3 suppresses the onset of symptoms and disease progression of G93A-SOD1 mouse model of ALS / Exp Neurol 205 : 336 ~ 346
Fornai F / 2008 / Autophagy and amyotrophic lateral sclerosis: The multiple roles of lithium / Autophagy 4 : 527 ~ 530
Fornai F / 2008 / Lithium delays progression of amyotrophic lateral sclerosis / Proc Natl Acad Sci USA 105 : 2052 ~ 2057
Harrison DE / 2009 / Rapamycin fed late in life extends lifespan in genetically heterogeneous mice / Nature 460 : 392 ~ 395
Koh SH / 007 / Inhibition of glycogen synthase kinase-3 suppresses the onset of symptoms and disease progression of G93A-SOD1 mouse model of ALS / Exp Neurol 205 : 336 ~ 346
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