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자료유형
학술저널
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대한임상신경생리학회 Annals of Clinical Neurophysiology Annals of Clinical Neurophysiology 제16권 제2호
발행연도
2014.1
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62 - 69 (8page)

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Background: Neuromodulation therapy has been used to an adjunctive treatment promoting motor recovery in strokepatients. The objective of the study was to determine the effect of repetitive transcranial magnetic stimulation (rTMS)on neurobehavioral recovery and evoked potentials in rats with middle cerebral artery occlusion. Methods: SeventySprague-Daley rats were induced permanent middle cerebral artery occlusion (MCAO) stroke model and successfulstroke rats (n=56) assigned to the rTMS (n=28) and sham (n=28) group. The 10 Hz, high frequency rTMS gave onipsilesional forepaw motor cortex during 2 weeks in rTMS group. The somatosensory evoked potential (SSEP) and motorevoked potential (MEP) were used to evaluate the electrophysiological changes. Behavioral function of the strokerat was evaluated by the Rota rod and Garcia test. Results: Forty rats (NrTMS=20; Nsham=20) completed all experimentalcourse. The rTMS group showed better performance than sham group in Rota rod test and Garcia test at day 11(p<0.05) but not day 18 (p>0.05). The amplitude of MEP and SSEP in rTMS group was larger than sham group atday 18 (p<0.05). Conclusions: These data confirm that the high frequency rTMS on ipsilesional cerebral motor cortexcan help the early recovery of motor performance in permanent middle cerebral artery stroke model and it may simultaneouslyassociate with changes in neurophysiological activity in brain.(Korean J Clin Neurophysiol 2014;16:62-69)

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