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The Guillain-Barre syndrome (GBS) is characterized by acute flaccid paralysis, areflexia, and albuminocytologic dissociation. GBS has several subtypes that are divided by clinical, electrophysiological, and pathological findings. Acute motor axonal neuropathy (AMAN) as a main form of Guillain-Barre syndrome was originally characterized by primary axonal degeneration. AMAN has been associated with extensive axonal loss and poor outcome. However, there are some cases of AMAN with rapid resolution of weakness and nerve conduction block. Rapid recovery from conduction block without temporal dispersion is called reversible conduction failure (RCF). Previous reports indicated anti-GM1 antibodies are related to AMAN with RCF. However, we experienced anti-GD1a and anti-GT1b antibodies positive and anti-GM1 antibody negative AMAN patient showing RCF. It suggests AMAN with RCF may be related to other anti ganglioside antibodies as well as anti-GM1 antibody. Moreover we would like to emphasize serial nerve conduction studies to confirm subtypes of GBS and also predict different outcomes.

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