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The aim of this study was to examine IL-15 expression after acute and chronic resistance training in rat skeletal muscle. Thirty-two male Sprague-Dawley rats were divided into sedentary control group (CON, n=8), acute resistance exercise group (ARE, n=16), and chronic resistance training group (CRT, n=8). The rats in CRT were trained to climb a ladder with weights secured to their tail 3 days/week for 8 weeks progressively, whereas acute exercised rats were climbed the ladder 10 times, and then sacrificed. IL-15 concentration in response to acute bout of resistance exercise was markedly increased (p<0.05) and peaked 1 hour after exercise compared to resting level, then returned to the resting level at 6 hours after resistance exercise in both soleus (SOL) and tibialis anterior (TA). After 8 weeks resistance training, significant higher concentration of IL-15 in SOL was found compared to the CON (p<0.05), while there was no significant change in IL-15 level in TA. These data are the first to demonstrate the changes in IL-15 level after the acute and chronic resistance exercise according to muscle fiber types.

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