지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 222 - 230 (9page)
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초록· 키워드
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PTH and ibandronate are proven to be effective in reversing negative effects of postmenopausal osteoporosis in terms of bone architecture and density. However, the changes of viscoelastic properties of the bone during the pathogenesis of osteoporosis and its treatment were seldom studied. Thus, this study aimed at studying the viscoelastic changes in PTH and ibandronate treated ovariectomized rat to assess the efficacy of the treatments. In this study, distal femurs of twenty-two female rats from four different groups (SHM, OVX, PTH and IBN) were evaluated using CT, pQCT and nanoindentation tests. While density parameters were well preserved in ibandronate treated group, elastic modulus and hardness were found to be better in PTH treated group. Thus, cortical and trabecular bone could be differentially affected by these two categories of drug, due to their difference in the action of mechanism. Moreover, viscosity of the cortical bone showed a positive correlation (R2=0.72) with bone strength predictor SSIy, which would possibly correlate with fracture risk.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Ammann P / 2007 / Strontium ranelate treatment improves trabecular and cortical intrinsic bone tissue quality, a determinant of bone strength / J Bone Miner Res 22 : 1419 ~ 1
Bauss F / 2002 / Total administered dose of ibandronate determines its effects on bone mass and architecture in ovariectomized aged rats / J Rheumatol 29 : 990 ~ 998
Brennan TC / 2009 / Selective modification of bone quality by PTH, pamidronate, or raloxifene / J Bone Miner Res 24 : 800 ~ 808
Buie HR / 2007 / Automatic segmentation of cortical and trabecular compartments based on a dual threshold technique for in vivo micro-CT bone analysis / Bone 41 : 505 ~ 515
Campbell GM / 2008 / Signs of irreversible architectural changes occur early in the development of experimental osteoporosis as assessed by in vivo micro-CT / Osteoporos Int
Bauss F / 2002 / Total administered dose of ibandronate determines its effects on bone mass and architecture in ovariectomized aged rats / J Rheumatol 29 : 990 ~ 998
Brennan TC / 2009 / Selective modification of bone quality by PTH, pamidronate, or raloxifene / J Bone Miner Res 24 : 800 ~ 808
Buie HR / 2007 / Automatic segmentation of cortical and trabecular compartments based on a dual threshold technique for in vivo micro-CT bone analysis / Bone 41 : 505 ~ 515
Campbell GM / 2008 / Signs of irreversible architectural changes occur early in the development of experimental osteoporosis as assessed by in vivo micro-CT / Osteoporos Int
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