지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 109 - 116 (8page)
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초록· 키워드
오류제보하기
Adefovir dipivoxil is used antiviral agent in the treatment of chronic hepatitis B virus infection. This drug is recommended for patients infected with lamivudine-refractory hepatitis B. Many studies of low-dose adefovir have shown little evidence of renal tubular dysfunction. However, hypophosphatemic osteomalacia has recently been reported in patients treated with adefovir. We report three cases of low dose adefovir-induced hypophosphatemic osteomalacia with fractures. All three patients had been receiving adefovir due to lamivudine-refractory hepatitis B, presented multiple bone pain. The laboratory tests revealed hypophosphatemia and phosphaturia. Bone scintigraphy showed increased uptake in multiple lesions. They were diagnosed as adefovir induced hypophophatemic osteomalacia. Changing the antiviral agent and administration of calcitriol and phosphates improved hypophosphatemia and clinical symptoms. Patients with hepatitis B virus treated with adefovir should be monitored with the serum phosphate levels and presenting symptoms of diffuse bone pain, clinicians need to suspect this infrequent complication.
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참고문헌 (11)
참고문헌 신청
Eguchi H / 2014 / Hypophosphatemic osteomalacia due to drug-induced fanconi’s syndrome associated with adefovir dipivoxil treatment for hepatitis B / Intern Med 53 : 233 ~ 2
Izzedine H / 2004 / Renal safety of adefovir dipivoxil in patients with chronic hepatitis B: two double-blind, randomized, placebo-controlled studies / Kidney Int 66 : 1153 ~
Lee KS / 2007 / Management of chronic hepatitis B / Korean J Hepatol 13 : 447 ~ 488
Luxon BA / 2011 / Bone disorders in chronic liver disease / Curr Gastroenterol Rep 13 : 40 ~ 48
Wang BF / 2015 / Osteomalacia and Fanconi's syndrome caused by long-term low-dose adefovir dipivoxil / J Clin Pharm Ther 40 : 345 ~ 348
Izzedine H / 2004 / Renal safety of adefovir dipivoxil in patients with chronic hepatitis B: two double-blind, randomized, placebo-controlled studies / Kidney Int 66 : 1153 ~
Lee KS / 2007 / Management of chronic hepatitis B / Korean J Hepatol 13 : 447 ~ 488
Luxon BA / 2011 / Bone disorders in chronic liver disease / Curr Gastroenterol Rep 13 : 40 ~ 48
Wang BF / 2015 / Osteomalacia and Fanconi's syndrome caused by long-term low-dose adefovir dipivoxil / J Clin Pharm Ther 40 : 345 ~ 348
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