지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 359 - 366 (8page)
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초록· 키워드
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Although advances in neonatal intensive care have led to an improved survival rate of extremely low birth weight infants, prolonged hospitalization of these critically ill infants has rendered them to be vulnerable to fungal infection in NICU. Because the incidence of fungal infection with related mortality and morbidity is inversely related to gestational age and birth weight, preventive measure is imperative to improve the survival rate and the outcome. There are many evidence-based reports for antifungal prophylaxis with fluconazole target infants <1,000 g and/or ≤27 weeks, because this group has a high infection-related mortality and neurodevelopmental impairment among survivors. However, interventions should begin with prenatal initiatives,with women being treated for vaginal candidiasis, especially with preterm labor.
Furthermore, policies for restrictive use of third-generation cephalosporins, H2-antagonists, proton pump inhibitors, and postnatal dexamethasone; follow of the guideline for central venous catheter care and removal; and feeding practices, with promotion of early feedings and breast milk, and supplementation with lactoferrin and or probiotics, may reduce the fungal infection. In conclusion, prophylactic systemic antifungal therapy along with comprehensive infection control measures,restrictive use of drugs and proper feeding practice reduce the incidence of invasive fungal infection in high risk very low birth weight infants in NICU. However, further study is needed for the routine use of prophylactic antifungal therapy because the effect on mortality rate was not significant and the data on the long-term neurodevelopmental consequences were limited. In addition, further data on the emergence of resistant organisms and Malassezia colonization are needed.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Austin N / 2013 / Prophylactic oral/topical non-absorbed antifungal agents to prevent invasive fungal infection in very low birth weight infants / Cochrane Database Syst Rev
Austin N / 2013 / Prophylactic systemic antifungal agents to prevent mortality and morbidity in very low birth weight infants / Cochrane Database Syst Rev 4 : CD003850 ~
Benjamin DK Jr / 2006 / Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months / Ped
Campbell JR / 2000 / Systemic candidiasis in extremely low birth weight infants receiving topical petrolatum ointment for skin care: a case-control study / Pediatrics 105 :
Choi IS / 2002 / Prevalence and risk factors of candida sepsis in neonatal intensive care unit / J Korean Pediatr Soc 45 : 836 ~ 846
Austin N / 2013 / Prophylactic systemic antifungal agents to prevent mortality and morbidity in very low birth weight infants / Cochrane Database Syst Rev 4 : CD003850 ~
Benjamin DK Jr / 2006 / Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months / Ped
Campbell JR / 2000 / Systemic candidiasis in extremely low birth weight infants receiving topical petrolatum ointment for skin care: a case-control study / Pediatrics 105 :
Choi IS / 2002 / Prevalence and risk factors of candida sepsis in neonatal intensive care unit / J Korean Pediatr Soc 45 : 836 ~ 846
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