지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Glucocorticoid (GC) excess, including Cushing’s syndrome, is a common cause of sec-ondary osteoporosis. Thirty to fifty percent of Cushing’s syndrome patients experiencenon-traumatic fractures, which is often the presenting manifestation of Cushing’s syn-drome. However, there have been rare cases of Cushing’s syndrome diagnosed onlybased upon bone manifestations. We describe a case of Cushing’s syndrome that was di-agnosed in a 44-year-old woman who initially visited our hospital due to multiple non-traumatic rib fractures. She did not exhibit any other manifestations of Cushing’s syn-drome such as moon face, buffalo hump or abdominal striae. Initially, we evaluated herfor bone metastases from a cancer of unknown origin, but there was no evidence ofmetastatic cancer. Instead, we found a left adrenal incidentaloma. As a result of the hor-mone study, she was diagnosed as having Cushing’s syndrome. Interestingly, her bonymanifestation of Cushing’s syndrome, which was evident in the bone scan and bonemineral densitometry, completely recovered after a left adrenalectomy. Therefore, thepossibility of Cushing’s syndrome as a cause of secondary osteoporosis should be con-sidered in young patients with non-traumatic multiple fractures, with or without anyother typical features of Cushing’s syndrome.
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참고문헌 (20)
참고문헌 신청
Arnaldi G. / 2003 / Diagnosis and complications of Cushing’s syndrome: a consensus statement / J Clin Endocrinol Metab. 88 : 5593 ~ 5602
Boscaro M. / 2001 / Cushing’s syndrome / Lancet. 357 : 783 ~ 791
Camozzi V. / 2010 / Persistent increase of osteoprotegerin levels after cortisol normalization in patients with Cushing’s syndrome / Eur J Endocrinol. 162 : 85 ~ 90
Canalis E. / 1996 / Clinical review 83: mechanisms of glucocorticoid action in bone: implications to glucocorticoid-induced osteoporosis / J Clin Endocrinol Metab. 81 : 3441
Di Somma C. / 2003 / Effect of 2 years of cortisol normalization on the impaired bone mass and turnover in adolescent and adult patients with Cushing’s disease: a prospecti
Boscaro M. / 2001 / Cushing’s syndrome / Lancet. 357 : 783 ~ 791
Camozzi V. / 2010 / Persistent increase of osteoprotegerin levels after cortisol normalization in patients with Cushing’s syndrome / Eur J Endocrinol. 162 : 85 ~ 90
Canalis E. / 1996 / Clinical review 83: mechanisms of glucocorticoid action in bone: implications to glucocorticoid-induced osteoporosis / J Clin Endocrinol Metab. 81 : 3441
Di Somma C. / 2003 / Effect of 2 years of cortisol normalization on the impaired bone mass and turnover in adolescent and adult patients with Cushing’s disease: a prospecti
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