지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objective: To compare the treatment thresholds for osteoporosis medication based on bone mineral density (BMD) results and fracture risk assessment tool (FRAX) risks in patients with a distal radius fracture.
Methods: The data of 116 consecutive women aged 50~89 years (mean 64.5 years) with a distal radius fracture were collated to identify clinical risk factors, which were inserted into the FRAX algorithm to calculate 10-year fracture risks. Proportions of patients indicated for osteoporosis medication based on BMD alone and based on FRAX risks were determined. Sensitivity estimation was done with FRAX plus BMD as a gold standard measurement for osteoporosis treatment.
Results: Of the 116 patients, 38% needed osteoporosis medication based on BMD alone, and 41% were indicated for treatment based on FRAX plus BMD. These proportions were not significantly different (P = 0.481). However, 56% of patients were indicated for treatment based on FRAX excluding BMD, which was significantly larger than the proportion determined by BMD alone (P = 0.001) or FRAX plus BMD (P = 0.003). Sensitivity, specificity, positive predictive value,negative predictive value for BMD alone were 75%, 93%, 90%, 82% and those for FRAX without BMD were 83%, 70%,69%, 84%.
Conclusion: No difference was found in the proportion of patients that need osteoporosis medication based on BMD results alone and FRAX plus BMD risks, suggesting BMD measurement can be sufficient to detect candidates for osteoporosis medication in patients with a distal radius fracture. FRAX excluding BMD may include too many patients that do not need osteoporosis treatment. [Korean Journal of Bone Metabolism, 18(1): 15-21, 2011
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참고문헌 (23)
참고문헌 신청
Berry SD / 2010 / Application of the National Osteoporosis Foundation Guidelines to postmenopausal w
Black DM / 1996 / Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group / Lance
Cuddihy MT / 2002 / Osteoporosis intervention following distal forearm fractures: a missed opportunity / Arch Intern Med 162 : 421 ~ 426
Dawson-Hughes B / 2008 / Implications of absolute fracture risk assessment for osteoporosis practice guidelines in the USA / Osteoporos Int 19 : 449 ~ 458
Earnshaw SA / 1998 / Colles' fracture of the wrist as an indicator of underlying osteoporosis in postmenopausal women: a prospective study of bone mineral density and bone tu
Black DM / 1996 / Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group / Lance
Cuddihy MT / 2002 / Osteoporosis intervention following distal forearm fractures: a missed opportunity / Arch Intern Med 162 : 421 ~ 426
Dawson-Hughes B / 2008 / Implications of absolute fracture risk assessment for osteoporosis practice guidelines in the USA / Osteoporos Int 19 : 449 ~ 458
Earnshaw SA / 1998 / Colles' fracture of the wrist as an indicator of underlying osteoporosis in postmenopausal women: a prospective study of bone mineral density and bone tu
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