지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Advocacy for the use of calcium supplements arose at a time when there were no othereffective interventions for the prevention of osteoporosis. Their promotion was basedon the belief that increasing calcium intake would increase bone formation. Our currentunderstandings of the biology of bone suggest that this does not occur, though calciumdoes act as a weak antiresorptive. Thus, it slows postmenopausal bone loss but, despitethis, recent meta-analyses suggest no significant prevention of fractures. In sum, there islittle substantive evidence of benefit to bone health from the use of calcium supple-ments. Against this needs to be balanced the likelihood that calcium supplement use in-creases cardiovascular events, kidney stones, gastrointestinal symptoms, and admis-sions to hospital with acute gastrointestinal problems. Thus, the balance of risk and ben-efit seems to be consistently negative. As a result, current recommendations are to ob-tain calcium from the diet in preference to supplements. Dietary calcium intake has notbeen associated with the adverse effects associated with supplements, probably be-cause calcium is provided in smaller boluses, which are absorbed more slowly since theycome together with quantities of protein and fat, resulting in a slower gastric transittime. These findings suggest that calcium supplements have little role to play in themodern therapeutics of osteoporosis, which is based around the targeting of safe andeffective anti-resorptive drugs to individuals demonstrated to be at increased risk of fu-ture fractures.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Anderson JJ. / 2012 / Calcium intakes and femoral and lumbar bone density of elderly U.S. men and women: National Health and Nutrition Examination Survey 2005-2006 analysis /
Bischoff-Ferrari HA. / 2007 / Calcium intake and hip fracture risk in men and women: a meta-analysis of prospective cohort studies and randomized controlled trials / Am J Cli
Bolland MJ. / 2008 / Vascular events in healthy older women receiving calcium supplementation: randomised controlled trial / BMJ. 336 : 262 ~ 269
Bolland MJ. / 2010 / Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis / BMJ. 341 : c3691 ~
Bolland MJ. / 2011 / Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and
Bischoff-Ferrari HA. / 2007 / Calcium intake and hip fracture risk in men and women: a meta-analysis of prospective cohort studies and randomized controlled trials / Am J Cli
Bolland MJ. / 2008 / Vascular events in healthy older women receiving calcium supplementation: randomised controlled trial / BMJ. 336 : 262 ~ 269
Bolland MJ. / 2010 / Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis / BMJ. 341 : c3691 ~
Bolland MJ. / 2011 / Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and
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