지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 98 - 101 (4page)
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초록· 키워드
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Clinical guidelines for initial management and long-term follow-up of thyroid cancer have been published from many societies world-widely, but there are still many unanswered clinical situation by conventional approach.
The prognostic role of BRAF V600E mutation status in patients with papillary thyroid microcarcinoma has been reported and surgical extent could be guided by preoperative assessment of BRAF V600E status from fine needle aspirates. The most important prognostic parameters thyroid cancer after total thyroidectomy and radioactive iodine treatment is measurement of serum thyroglobulin (Tg). Thyrolgobulin autoantiboies (TgAb)is detected up to 25 percent of thyroid cancer patients and may be potential cause of false negative Tg.
To overcome this caveat, measurement of transcript of thyroid tissue specific gene could be a substitute for Tg. Serum Tg measurement is also not helpful for thyroid cancer patients who received partial thyroidectomy.
Because Tg is tissue specific marker, not cancer specific marker, i.e. normal remnant thyroid tissue could be potential source of Tg. Recent approach to measure BRAF V600E mutation from peripheral blood could be a good candidate tumor marker in patients with normal remnant thyroid tissue. Recent introduction of novel molecular markers for thyroid cancer could be a promising answer to previous guideline for individualize follow-up of thyroid cancer patients.
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참고문헌 (19)
참고문헌 신청
Barzon L / 2004 / Evaluation of circulating thyroid-specific transcripts as markers of thyroid cancer relapse / Int J Cancer 110 (6) : 914 ~ 920
Basolo F / 2010 / Correlation between the BRAF V600E mutation and tumor invasiveness in papillary thyroid carcinomas smaller than 20 millimeters: analysis of 1060 cases / J C
Chinnappa P / 2004 / Detection of thyrotropin-receptor messenger ribonucleic acid (mRNA) and thyroglobulin mRNA transcripts in peripheral blood of patients with thyroid dise
Chung KW / 2006 / Detection of BRAFV600E mutation on fine needle aspiration specimens of thyroid nodule refines cyto-pathology diagnosis, especially in BRAF600E mutation-pre
Cooper DS / 2009 / Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer / Thyroid 19 (11) : 1167 ~ 1
Basolo F / 2010 / Correlation between the BRAF V600E mutation and tumor invasiveness in papillary thyroid carcinomas smaller than 20 millimeters: analysis of 1060 cases / J C
Chinnappa P / 2004 / Detection of thyrotropin-receptor messenger ribonucleic acid (mRNA) and thyroglobulin mRNA transcripts in peripheral blood of patients with thyroid dise
Chung KW / 2006 / Detection of BRAFV600E mutation on fine needle aspiration specimens of thyroid nodule refines cyto-pathology diagnosis, especially in BRAF600E mutation-pre
Cooper DS / 2009 / Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer / Thyroid 19 (11) : 1167 ~ 1
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