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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 89 - 95 (7page)
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Background and Objectives: Blood neutrophil-to-lymphocyte ratio (NLR) has been reported to have poor prognostic impact in variable malignancies. However, studies evaluating the clinical significance of blood NLR in patient with papillary thyroid carcinoma (PTC) has been relatively rare, and the outcomes were inconsistent.
In this study, we sought to analyze the clinical value of NLR in patients with PTC who had cervical lymph node metastasis. Materials and Methods: Retrospective chart review was conducted with 174 patients with confirmed neck metastasis of PTC after initial thyroidectomy. Blood NLR was estimated by dividing the absolute number of blood neutrophil with that of lymphocyte. Statistical analysis was conducted to evaluate correlation between NLR and clinicopathologic factors, patterns of metastatic lymph nodes, and recurrence. Results: Higher NLR (＞1.74) was correlated to younger age of patients (＜45 years, p=0.045) and smaller size of tumor (＜1 cm, p=0.017). Blood NLR had no impact on patterns of lymph node metastasis or recurrence. Conclusion: Blood NLR may not be considered as a predictive factor for clinical aggressiveness or prognosis in patients with PTC with lymph node metastasis.
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참고문헌 (21)
참고문헌 신청
Gong W / 2016 / Blood preoperative neutrophil-to-lymphocyte ratio is correlated with TNM stage in patients with papillary thyroid cancer / Clinics (Sao Paulo) 71 (6) : 311 ~
Grivennikov SI / 2010 / Immunity, inflammation, and cancer / Cell 140 (6) : 883 ~ 8
Gu X / 2016 / Prognostic significance of neutrophil-to-lymphocyte ratio in prostate cancer:evidence from 16,266 patients / Sci Rep 6 : 22089 ~
Haugen BR / 2016 / 2015 American Thyroid Association Management Guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American Thyroid Ass
Ito Y / 2009 / Prognostic factors and therapeutic strategies for differentiated carcinomas of the thyroid / Endocr J 56 (2) : 177 ~ 192
Grivennikov SI / 2010 / Immunity, inflammation, and cancer / Cell 140 (6) : 883 ~ 8
Gu X / 2016 / Prognostic significance of neutrophil-to-lymphocyte ratio in prostate cancer:evidence from 16,266 patients / Sci Rep 6 : 22089 ~
Haugen BR / 2016 / 2015 American Thyroid Association Management Guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American Thyroid Ass
Ito Y / 2009 / Prognostic factors and therapeutic strategies for differentiated carcinomas of the thyroid / Endocr J 56 (2) : 177 ~ 192
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