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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 96 - 101 (6page)
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Background and Objectives: Anaplastic thyroid carcinoma (ATC) is commonly related with concurrent differentiated thyroid carcinoma (DTC). We aimed to examine the clinicopathologic characteristics, prognosis and gene expression of DTC with anaplastic foci. Materials and Methods: Eighteen patients with DTC with anaplastic foci were enrolled in this study. To compare the clinicopathologic characteristics and prognosis of anaplastic foci subjects with conventional ATC or DTC, we additionally included 12 ATC and 1030 DTC patients who diagnosed during same period. Immunohistochemistry was performed to check the gene expression in anaplastic foci and DTC component. Results: In anaplastic foci group, tumor size was larger (2.5±1.3 vs. 1.2±0.9 cm, p=0.001), distant metastasis was more frequent (11.1 vs. 0%, p=0.000) and 1-year survival rate was low (88.9 vs. 100%, p=0.000) than DTC group. In contrast, compared with ATC group, anaplastic foci group showed younger age at diagnosis (50±16 vs. 63±18 years, p=0.039), smaller tumor size (2.5±1.3 vs. 3.8±1.4 cm, p=0.027), less distant metastasis (11.1 vs. 41.7%, p=0.084) and longer 1-year survival rate (88.9 vs. 25.0%, p=0.001). Expression of p53 protein was observed in 100% of anaplastic foci, ATC and 12.5% of papillary thyroid carcinoma component. Conclusion: DTC with foci of anaplastic transformation has a worse prognosis than DTC, but a better prognosis than ATC. Our results support that DTC with anaplastic foci was intermediate state from DTC to ATC.
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참고문헌 (23)
참고문헌 신청
Albores-Saavedra J / 2007 / Changing patterns in the incidence and survival of thyroid cancer with follicular phenotype--papillary, follicular, and anaplastic: a morphologic
Haigh PI / 2001 / Completely resected anaplastic thyroid carcinoma combined with adjuvant chemotherapy and irradiation is associated with prolonged survival / Cancer 91 (12)
Han JM / 2012 / Time trend in tumour size and characteristics of anaplastic thyroid carcinoma / Clin Endocrinol (Oxf) 77 (3) : 459 ~ 464
Hunt JL / 2003 / Molecular evidence of anaplastic transformation in coexisting well-differentiated and anaplastic carcinomas of the thyroid / Am J Surg Pathol 27 (12) : 1559
Ibanez ML / 1966 / Thyroid carcinoma--biologic behavior and mortality. Postmortem findings in 42 cases, including 27 in which the disease was fatal / Cancer 19 (8) : 1039 ~
Haigh PI / 2001 / Completely resected anaplastic thyroid carcinoma combined with adjuvant chemotherapy and irradiation is associated with prolonged survival / Cancer 91 (12)
Han JM / 2012 / Time trend in tumour size and characteristics of anaplastic thyroid carcinoma / Clin Endocrinol (Oxf) 77 (3) : 459 ~ 464
Hunt JL / 2003 / Molecular evidence of anaplastic transformation in coexisting well-differentiated and anaplastic carcinomas of the thyroid / Am J Surg Pathol 27 (12) : 1559
Ibanez ML / 1966 / Thyroid carcinoma--biologic behavior and mortality. Postmortem findings in 42 cases, including 27 in which the disease was fatal / Cancer 19 (8) : 1039 ~
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