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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 21 - 25 (5page)
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초록· 키워드
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Thyroid hormone plays an important role in bone remodeling. In overt hyperthyroidism, excess thyroid hormone accelerates bone turnover and shortens the normal bone remodeling cycle, leading osteoporosis and increased fracture risk. Several population and case-control studies have demonstrated that a prior history of hyperthyroidism is an independent risk factor for hip and vertebral fracture. In contrast, bone remodeling cycle is prolonged to almost 2 years with an increase in mineralized cortical bone in overt hypothyroidism. Some cross-sectional and longitudinal studies have suggested that thyroid hormone replacement could decrease bone mineral density in overt hypothyroidism. However, this effect might be interpreted as an adaptive mechanism on decreased bone turnover in preexistent hypothyroidism, and not as thyroid hormone induced bone loss. The effect of thyroid hormone replacement for hypothyroidism on fracture risk has not been investigated well. However, excessive thyroid hormone treatment might be increased the risk of fracture.
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등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Korean Endocrine Society / Osteoporosis Fact Sheet 2014
Park C / 2011 / The incidence and residual lifetime risk of osteoporosis-related fractures in Korea / J Bone Miner Metab 29(6):744~751
Vestergaard P / 2003 / Hyperthyroidism, bone mineral, and fracture risk--a meta-analysis / Thyroid 13(6):585~593
Cho BY / 2014 / Clinical thyroidology / Korea Medical Book :11~24
Bianco AC / 2002 / Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases / Endocr Rev 23(1):38~89
Park C / 2011 / The incidence and residual lifetime risk of osteoporosis-related fractures in Korea / J Bone Miner Metab 29(6):744~751
Vestergaard P / 2003 / Hyperthyroidism, bone mineral, and fracture risk--a meta-analysis / Thyroid 13(6):585~593
Cho BY / 2014 / Clinical thyroidology / Korea Medical Book :11~24
Bianco AC / 2002 / Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases / Endocr Rev 23(1):38~89
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