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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 163 - 168 (6page)
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The effect of Allium hookeri extracts on the melanogenesis in mouse melanoma B16F10 was studied asa raw material of functional cosmetics. Allium hookeri has been associated with the traditional recipes ofmeiteis and also with the ethnotherapy of certain diseases by local herlers since the time immemorial,the plant has been regarded as ethnobotanic relevance to the Manipuris. The effect of Allium hookeriextracts has found that the secreted melanin in culture medium was reduced by 50% at the concentrationof 0.064%. At this concentration, tyrosinase activity was reduced by 20%. On the other hand, Tyrosinaseexpression level was reduced by 93% at the same concentration comparing to the case of positive control. TRP1 and TRP2 expression levels were also reduced as much as 70%. The expression levels of theenzymes necessary for the melanogenesis were confirmed by western blotting. This is the first study aboutmelanogenesis inhibitory effect of Allium hookeri extracts. However, it is not yet clear which compound iseffective in anti-melanogenesis. Further studies are necessary to elucidate the detail mechanism.
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참고문헌 (28)
참고문헌 신청
[학
Ando H / 2007 / Approaches to identify inhibitors of melanin biosynthesis via the quality control of tyrosinase / J. Invest. Dermatol 127 : 751 ~ 761
Arung ET / 2011 / Anti-melanogenesis properties of quercetin- and its derivative-rich extract form Allium cepa / Food Chemistry 124 : 1024 ~ 1028
Baek YS / 2009 / Tyrosinase inhibitory effects of 1,3-dipheylpropanes from Broussonetia kazinoki / Bioorg. Med. Chem 17 : 35 ~ 41
Brenner M / 2008 / Modifying skin pigmentationapproaches through intrinsic biochemistry and exogeneous agents / Drug. Discov. Today. Dis. Mech 5 : 189 ~ 199
Ando H / 2007 / Approaches to identify inhibitors of melanin biosynthesis via the quality control of tyrosinase / J. Invest. Dermatol 127 : 751 ~ 761
Arung ET / 2011 / Anti-melanogenesis properties of quercetin- and its derivative-rich extract form Allium cepa / Food Chemistry 124 : 1024 ~ 1028
Baek YS / 2009 / Tyrosinase inhibitory effects of 1,3-dipheylpropanes from Broussonetia kazinoki / Bioorg. Med. Chem 17 : 35 ~ 41
Brenner M / 2008 / Modifying skin pigmentationapproaches through intrinsic biochemistry and exogeneous agents / Drug. Discov. Today. Dis. Mech 5 : 189 ~ 199
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