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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 403 - 408 (6page)
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초록· 키워드
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Although previous studies have identified that both the fruit and leaf of dangyuja (Citrus grandis Osbeck) exhibits anticancer, antioxdant and anti-inflammatory effect, the inhibitory effect of melanogenesis have not been reported. In this study, freeze dried extract of dangyuja was evaluated for their potential to inhibit melanogenesis. Results show that, freeze dried extracts of dangyuja strongly decreased the tyrosinase activity for catalysis of L-dihydroxyphenylalanine (L-DOPA) oxidation in a dose–dependent manner. In addition, we also verified that cytotoxicity and melanin content in mouse B16F10 melanoma cells were assayed after treatment with the freeze dried extracts of dangyuja. The results demonstrate that extracts possessed low cytotoxic activity and that melanin content was reduced. Overall, freeze dried extracts of dangyuja is a safe natural materials that show an effective inhibition of melanogenesis. These results suggest that freeze dried extracts of dangyuja can be considered as an effective skin whitening reagent for application in cosmetics.
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참고문헌 (28)
참고문헌 신청
Akiu S / 1991 / Inhibitory effect of arbutin on melanogenesis--biochemical study using cultured B16 melanoma cells / Nihon Hifuka Gakkai Zasshi 101 : 609 ~ 613
Cabanes J / 1994 / Kojic acid, a cosmetic skin whitening agent, is a slow-binding inhibitor of catecholase activity of tyrosinase / J. Pharm. Pharmacol 46 : 982 ~ 985
Choi SS / 2001 / Screening of inhibitors against tyrosinase activity from natural products / Yakhak Hoeji 45 : 522 ~
Eisinger M / 1982 / Selective proliferation of normal human melanocytes in vitro in the presence of phorbol ester and choleratoxin / Proc. Natl. Acad. Sci. USA 79 : 2018 ~ 20
Gilchrest BA. / 2011 / Molecular aspects of tanning / J. Invest. Dermatol 131 : 14 ~ 17
Cabanes J / 1994 / Kojic acid, a cosmetic skin whitening agent, is a slow-binding inhibitor of catecholase activity of tyrosinase / J. Pharm. Pharmacol 46 : 982 ~ 985
Choi SS / 2001 / Screening of inhibitors against tyrosinase activity from natural products / Yakhak Hoeji 45 : 522 ~
Eisinger M / 1982 / Selective proliferation of normal human melanocytes in vitro in the presence of phorbol ester and choleratoxin / Proc. Natl. Acad. Sci. USA 79 : 2018 ~ 20
Gilchrest BA. / 2011 / Molecular aspects of tanning / J. Invest. Dermatol 131 : 14 ~ 17
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