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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Autophagy is a degradation pathway that targets many cellular components and plays a particularly important role inprotein degradation and recycling. This process is very complex and several proteins participate in this process. One ofthem, P62/SQSTM1, is related to the N-end rule and induces protein degradation through autophagy. The P62/SQSTM1makes a huge oligomer, and this oligomerization is known to play an important role in its mechanism. This oligomerizationtakes two steps. First, the PB1 domain of P62/SQSTM1 makes the base oligomer, and then, when the ligand binds to theZZ domain of P62/SQSTM1, it induces a higher oligomer by the disulfide bond of the two cysteines. To understand theoligomerization mechanism of P62/SQSTM1, we need to know the dimerization of the PB1 domain. In this study, crystalsof PB1 dimer were made and the crystals were diffracted by X-ray to collect usable data up to 3.2A. We are analyzing thestructure using the molecular replacement (MR) method.
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참고문헌 (13)
참고문헌 신청
Adams, P. D / 2010 / PHENIX : a comprehensive Python-based system for macromolecular structure solution / Acta Crystallogr D Biol Crystallogr 66:213~221
Bjorkoy, G / 2005 / p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death / J Cell Biol 171:603~614
Cha-Molstad, H / 2017 / p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis / Nat Commun 8:102
Ciuffa, R / 2015 / The selective autophagy receptor p62 forms a flexible filamentous helical scaffold / Cell Rep 11:748~758
Komatsu, M / 2010 / The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 / Nat Cell Biol 12:213~223
Bjorkoy, G / 2005 / p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death / J Cell Biol 171:603~614
Cha-Molstad, H / 2017 / p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis / Nat Commun 8:102
Ciuffa, R / 2015 / The selective autophagy receptor p62 forms a flexible filamentous helical scaffold / Cell Rep 11:748~758
Komatsu, M / 2010 / The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 / Nat Cell Biol 12:213~223
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