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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
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- 영남대학교 의과대학 Journal of Yeungnam Medical Science Yeungnam University Journal of Medicine 제34권 제1호
- 발행연도
- 2017.1
- 수록면
- 19 - 28 (10page)
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The incidence of type 2 diabetes mellitus and insulin resistance is growing rapidly. Multiple organs including the liver, skeletal muscle and adipose tissue control insulin sensitivity coordinately, but the mechanism of skeletal muscle insulin resistance has not yet been fully elucidated. However, there is a growing body of evidence that lipotoxicity induced by mitochondrial dysfunction in skeletal muscle is an important mediator of insulin resistance. However, some recent findings suggest that skeletal mitochondrial dysfunction generated by genetic manipulation is not always correlated with insulin resistance in animal models. A high fat diet can provoke insulin resistance despite a coordinate increase in skeletal muscle mitochondria, which implies that mitochondrial dysfunction is not mandatory in insulin resistance. Furthermore, incomplete fatty acid oxidation by excessive nutrition supply compared to mitochondrial demand can induce insulin resistance without preceding impairment of mitochondrial function. Taken together we suggested that skeletal muscle mitochondrial overloading, not mitochondrial dysfunction, plays a pivotal role in insulin resistance.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Bays H / 2004 / Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists pro
Befroy DE / 2008 / Increased substrate oxidation and mitochondrial uncoupling in skeletal muscle of endurance-trained individuals / Proc Natl Acad Sci U S A 105 (43) : 16701
Boushel R / 2007 / Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle / Diabetologia 50 : 790 ~ 796
Brown AE / 2008 / Does impaired mitochondrial function affect insulin signaling and action in cultured human skeletal muscle cells? / Am J Physiol Endocrinol Metab 294 : E97
DeFronzo RA / 1985 / Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus / J Clin Invest 76 : 149 ~ 155
Befroy DE / 2008 / Increased substrate oxidation and mitochondrial uncoupling in skeletal muscle of endurance-trained individuals / Proc Natl Acad Sci U S A 105 (43) : 16701
Boushel R / 2007 / Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle / Diabetologia 50 : 790 ~ 796
Brown AE / 2008 / Does impaired mitochondrial function affect insulin signaling and action in cultured human skeletal muscle cells? / Am J Physiol Endocrinol Metab 294 : E97
DeFronzo RA / 1985 / Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus / J Clin Invest 76 : 149 ~ 155
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