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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 영남대학교 의과대학 Journal of Yeungnam Medical Science Yeungnam University Journal of Medicine 제34권 제1호
- 발행연도
- 2017.1
- 수록면
- 43 - 54 (12page)
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Background: Extracellular sulfatases (Sulfs), sulfatase 1 (Sulf1) and sulfatase 2 (Sulf2), play a pivotal role in cell signaling by remodeling the 6-O-sulfation of heparan sulfate proteoglycans on the cell surface. The present study examined the effects of Sulfs on angiotensin II (Ang II)-induced hypertensive mediator expression and vascular smooth muscle cells (VSMCs) proliferation in spontaneously hypertensive rats (SHR).
Methods: Ang II receptors, 12-lipoxygenase (12-LO), and endothelin-1 (ET-1) messenger RNA (mRNA) expressions in SHR VSMCs were analyzed by real-time polymerase chain reaction and Western blotting. VSMCs proliferation was determined by [3H]-thymidine incorporation.
Results: Basal Sulfs mRNAs expression and enzyme activity were elevated in SHR VSMCs. However, Sulfs had no effect on the basal or Ang II-induced 12-LO and ET-1 mRNA expression in SHR VSMCs. The inhibition of Ang II-induced 12-LO and ET-1 expression by blockade of the Ang II type 2 receptor (AT2 R) pathway was not observed in Sulf1 siRNA-transfected SHR VSMCs. However, Sulf2 did not affect the action of AT2 R inhibitor on Ang II-induced 12-LO and ET-1 expression in SHR VSMCs. The down-regulation of Sulf1 induced a reduction of AT2 R mRNA expression in SHR VSMCs. In addition, the inhibition of Ang II-induced VSMCs proliferation by blockade of the AT2 R pathway was mediated by Sulf1 in SHR VSMCs.
Conclusion: These findings suggest that extracellular sulfatase Sulf1 plays a modulatory role in the AT2 R pathway that leads to an Ang II-induced hypertensive effects in SHR VSMCs.
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참고문헌 (23)
참고문헌 신청
Buono M / 2010 / Sulfatase activities towards the regulation of cell metabolism and signaling in mammals / Cell Mol Life Sci 67 : 769 ~ 780
Dai Y / 2005 / HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo / J Biol Chem 280 (48) : 40066 ~ 40073
Heintz B / 1995 / Decreased glomerular basement membrane heparan sulfate proteoglycan in essential hypertension / Hypertension 25 : 399 ~ 407
Holst CR / 2007 / Secreted sulfatases Sulf1 and Sulf2 have overlapping yet essential roles in mouse neonatal survival / PLoS One 2 : e575 ~
Honke K / 2002 / Sulfotransferases and sulfated oligosaccharides / Med Res Rev 22 : 637 ~ 654
Dai Y / 2005 / HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo / J Biol Chem 280 (48) : 40066 ~ 40073
Heintz B / 1995 / Decreased glomerular basement membrane heparan sulfate proteoglycan in essential hypertension / Hypertension 25 : 399 ~ 407
Holst CR / 2007 / Secreted sulfatases Sulf1 and Sulf2 have overlapping yet essential roles in mouse neonatal survival / PLoS One 2 : e575 ~
Honke K / 2002 / Sulfotransferases and sulfated oligosaccharides / Med Res Rev 22 : 637 ~ 654
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