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자료유형
학술저널
저자정보
저널정보
대한한방신경정신과학회 동의신경정신과학회지 동의신경정신과학회지 제16권 제1호
발행연도
2005.1
수록면
67 - 80 (14page)

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초록· 키워드

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This experiment was designed to investigate the effect of Rheum palmatum(RHP) on the Alzheimer's disease. The effects of RHP extract on amyloid precursor proteins(APP), acetylcholinesterase(AChE), glial fibrillary acidic protein(GFAP) mRNA of PC-12 cell treated by Aβ and IL-1β, IL-6, TNF-α mRNA of THP-1 celll treated by LPS and AChE activity of PC-12 cell lysate treated by Aβ and behavior of memory deficit rats induced by scopolamine and mice glucose, uric acid, AChE activity of memory deficit rats induced by scopolamine were investigated, respectively. The results were summarized as follows ; 1. RHP extract suppressed APP, AChE, GFAP mRNA in PC-12 cell treated by Aβ . 2. RHP extract suppressed IL-1β, IL-6 TNF-α mRNA in THP-1 celll treated by LPS. 3. RHP extract suppressed AChE activity in cell lysate of PC-12 cell treated by Aβ. 4. HP extract increased glucose, decreased uric acid and AChE significantly in the serum of the memory deficit rats induced by scopolamine. 5. RHP extract group showed significantly inhibitory effect on the memory deficit of mice induced by scopolamine in the experiment of Morris water maze. According to the above results, it is suggested that RHP extract might be usefully applied for prevention and treatment of Alzheimer's disease and memory deficit symptom.

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