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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 485 - 493 (9page)
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초록· 키워드
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The organic anion transporters (OATs) are expressed in various tissues, primarily in the kidney and liver, but they are also expressed in the placenta, small intestine, and the choroid plexus, which are all epithelial tissues that transport xenobiotics. Six isoforms of OATs are currently known. Considering the variety of organic anionic compounds, other OATs isoforms can be assumed. In this connection, we have searched for a new isoform in the expressed sequence tag (EST) database. We found the new candidate clone AK052752 in the mouse kidney cDNA library and we named it mouse organic anion transporter like protein 1 (mOATLP1). The mOATLP1 cDNA consisted of 2221 base pairs that encoded a 552 amino acid residue protein with 12 putative transmembrane domains. The deduced amino acid sequence of mOATLP1 showed 37 to 63% identity to other members of the OAT family. According to the tissue distribution based on Northern blot analysis, 2.7 kb and 2.9 kb mOATLP1 transcripts (approximate sizes) were observed in the kidney and liver. An 85-kDa band (approximate) was detected using Western blot analysis of mouse kidney performed with a synthesized oligopeptide-induced mOATLP1 antibody. Immunohistochemical results showed mOATLP1 was stained in the blood vessels, glomeruli (the parietal epithelial cells and podocytes), distal convoluted tubules, connecting tubules, and inner medullary collecting tubules. mOATLP1 appears to be a novel candidate for an organic anion transporter isoform identified in the kidney.
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참고문헌 (24)
참고문헌 신청
/ / Contraluminal transport systems in the proximal renal tubule involved in secretion of organic anions
/ 1923 / The mechanisms of the elimination of phenolsulphonphthalein by the kidney - a proof of secretion by the convoluted tubules 34 : 1 ~ 7
/ 1959 / Secretion of organic anions in the formation of urine and bile 11 : 109 ~ 34
/ 1982 / Renal organic anion transport system:pharmacological,physiological,and biochemical aspects 34 : 315 ~ 58
/ 1991 / Comparative insights into the mecha-nisms of renal organic anion and cation secretion 261
/ 1923 / The mechanisms of the elimination of phenolsulphonphthalein by the kidney - a proof of secretion by the convoluted tubules 34 : 1 ~ 7
/ 1959 / Secretion of organic anions in the formation of urine and bile 11 : 109 ~ 34
/ 1982 / Renal organic anion transport system:pharmacological,physiological,and biochemical aspects 34 : 315 ~ 58
/ 1991 / Comparative insights into the mecha-nisms of renal organic anion and cation secretion 261
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