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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 450 - 457 (8page)
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초록· 키워드
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Zinc finger protein 133 (ZNF133) is composed of a Krüppel-associated box (KRAB) domain and 14 contiguous zinc finger motifs. ZNF133 is regarded as a transcriptional repressor because the KRAB domain has potent repressor activity and the zinc finger motifs usually act in binding to DNA. However, we found that the zinc finger motifs of ZNF133 also possessed transcriptional repressor activity. By two-hybrid screening assay, we found that the zinc finger motifs of ZNF133 interacted with protein inhibitor of activated STAT1 (PIAS1). PIAS1 enhanced the transcriptional repression activity of ZNF133 through the zinc finger motifs. This effect of PIAS1 was relieved by an inhibitor of the histone deacetylases (HDACs). These results demonstrate that the transcriptional repressor activity of ZNF133 is regulated by both the KRAB domain and the zinc finger motifs, and that the repressive effect by zinc finger motifs is mediated by PIAS1.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Andersen K / 2003 / Interferon- gamma suppresses S100A4 transcription independently of apoptosis or cell cycle arrest 88 : 1995 ~ 2001
Friedman JR / 1996 / KAP-1, a novel corepressor for the highly conserved KRAB repression domain 10 : 2067 ~ 2078
Gross M / 2004 / PIASy-mediated repression of the androgen receptor is independent of sumoylation 23 : 3059 ~ 3066
Heiskanen MA / 2000 / Detection of gene amplification by genomic hybridization to cDNA microarrays 60 : 799 ~ 802
Kahyo T / 2001 / Involvement of PIAS1 in the sumoylation of tumor suppressor p53 8 : 713 ~ 718
Friedman JR / 1996 / KAP-1, a novel corepressor for the highly conserved KRAB repression domain 10 : 2067 ~ 2078
Gross M / 2004 / PIASy-mediated repression of the androgen receptor is independent of sumoylation 23 : 3059 ~ 3066
Heiskanen MA / 2000 / Detection of gene amplification by genomic hybridization to cDNA microarrays 60 : 799 ~ 802
Kahyo T / 2001 / Involvement of PIAS1 in the sumoylation of tumor suppressor p53 8 : 713 ~ 718
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