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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 583 - 595 (13page)
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초록· 키워드
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Replication-incompetent adenoviruses expressing
three major glycoproteins (gB, gC, and gD) of pseudorabies
virus (PrV) were constructed and used to examine
the ability of these glycoproteins to induce protective
immunity against a lethal challenge. Among
three constructs, recombinant adenovirus expressing
gB (rAd-gB) was found to induce the most potent immunity
biased to Th1-type, as determined by the IgG
isotype ratio and the profile of the Th1/Th2 cytokine
production. Conversely, the gC-expressing adenovirus
(rAd-gC) revealed Th2-type immunity and the gD-expressing adenovirus (rAd-gD) induced lower
levels of IFN-γ and IL-4 production than other constructs,
except IL-2 production. Mucosal delivery of
rAd-gB induced mucosal IgA and serum IgG responses
and biased toward Th2-type immune responses.
However, these effects were not observed in
response to systemic delivery of rAd-gB. In addition,
rAd-gB appeared to induce effective protective immunity
against a virulent viral infection, regardless of
whether it was administered via the muscular or systemic
route. These results suggest that administration
of replication-incompetent adenoviruses can induce
different types of immunity depending on the expressed
antigen and that recombinant adenoviruses
expressing gB induced the most potent Th1-biased humoral
and cellular immunity and provided effective
protection against PrV infection.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Ali M / 1994 / The use of DNA viruses as vectors for gene therapy / Gene therapy 1 : 367 ~ 84
Ambriovic A / 1997 / Efficacy of replication-defective adenovirus-vectored vaccines: protection following intramuscular injection is linked to promoter efficiency in muscle r
Babiuk LA / 2000 / Adenoviruses as vectors for delivering vaccines to mucosal surfaces / Journal of biotechnology 83 : 105 ~ 13
Barouch DH / 2005 / Adenovirus vector-based vaccines for human immunodeficiency virus type 1 / Human gene therapy 16 : 149 ~ 56
Bianchi AT / 1998 / A mouse model to study immunity against pseudorabies virus infection: significance of CD4+ and CD8+ cells in protective immunity / Vaccine 16 : 1550 ~ 8
Ambriovic A / 1997 / Efficacy of replication-defective adenovirus-vectored vaccines: protection following intramuscular injection is linked to promoter efficiency in muscle r
Babiuk LA / 2000 / Adenoviruses as vectors for delivering vaccines to mucosal surfaces / Journal of biotechnology 83 : 105 ~ 13
Barouch DH / 2005 / Adenovirus vector-based vaccines for human immunodeficiency virus type 1 / Human gene therapy 16 : 149 ~ 56
Bianchi AT / 1998 / A mouse model to study immunity against pseudorabies virus infection: significance of CD4+ and CD8+ cells in protective immunity / Vaccine 16 : 1550 ~ 8
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