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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 617 - 628 (12page)
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초록· 키워드
오류제보하기
Honokiol is an active compound purified from magnolia
that has been shown to induce cell differentiation,
apoptosis, and anti-angiogenesis effects, as well as an
enhancement in tumor growth delay in combination
with chemotherapeutic agents in several mouse xenograft
models. Our goal was to investigate the radiosensitization
effect of honokiol on lung carcinoma. The
radiosensitization effect of liposomal honokiol in
Lewis lung carcinoma cells (LL/2) was analyzed using
an in vitro clonogenic survival assay. For an in vivo
study, Lewis lung carcinoma-bearing C57BL/6 mice
were treated with either liposomal honokiol at 25 mg/kg
or 5 Gy of single tumor radiation, or a combination of
both over 12 days of treatment. The tumor growth delay
and the survival time were evaluated. In addition, histological
analysis of tumor sections was performed to examine
changes by detecting the microvessel density
and apoptosis in tumor tissues. In the clonogenic survival
assay, LL/2 cells treated with IC50 Lipo-HNK for 24
h showed a radiation enhancement ratio of 1.9. After
12 days of combination treatment, the tumor volume
decreased 78% and produced an anti-tumor activity
1.3-fold greater than a predicted additive effect of honokiol and radiation alone. This combination treatment
also caused an 8.7 day delay in tumor growth. The cell
cycle distribution and histological analysis demonstrated
that liposomal honokiol has an anti-tumor effect
via inducing apoptosis and inhibiting angiogenesis.
Liposomal honokiol can enhance tumor cell
radiosensitivity in vitro and in vivo, indicating that radiotherapy
combined with liposomal honokiol can
lead to greater anti-tumor efficacy.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Abdollahi A / 2003 / Combined therapy with direct and indirect angiogenesis inhibition results in enhanced antiangiogenic and antitumor effects / Cancer Res 63 : 8890 ~ 8
Abdollahi A / 2003 / SU5416 and SU6668 attenuate the angiogenic effects of radiationinduced tumor cell growth factor production and amplify the direct anti-endothelial action
Bai X / 2003 / Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo / J Biol Chem 278 : 35501 ~ 7
Belinsky SA / 2006 / Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort / Cancer Res 66 : 3338 ~ 44
Bello L / 1999 / Low-dose chemotherapy combined with an antiangiogenic drug reduces human glioma growth in vivo / Cancer Res 61 : 7501 ~ 6
Abdollahi A / 2003 / SU5416 and SU6668 attenuate the angiogenic effects of radiationinduced tumor cell growth factor production and amplify the direct anti-endothelial action
Bai X / 2003 / Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo / J Biol Chem 278 : 35501 ~ 7
Belinsky SA / 2006 / Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort / Cancer Res 66 : 3338 ~ 44
Bello L / 1999 / Low-dose chemotherapy combined with an antiangiogenic drug reduces human glioma growth in vivo / Cancer Res 61 : 7501 ~ 6
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