지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 694 - 705 (12page)
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초록· 키워드
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IL-17-producing CD4+ T cells (Th17) play important functions in autoimmune diseases and allograft rejection of solid organs. We examined the effects of IL 17 and its mechanism of action on arthritis in a murine collagen-induced arthritis (CIA) model using bone marrow transplantation (BMT) system. DBA/1J mice were administered a lethal radiation dose and then rescued with bone marrow derived from either wild-type (WT) or IL-17-/- mice on C57BL/6 background mice. CIA was induced after the bone marrow transplant, and disease progression was characterized. DBA/1J mice with CIA that received IL-17-/- donor bone marrow showed potently inhibited development and severity of clinical arthritis as compared with CIA mice that received WT bone marrow. Reduced secretion of the pro-inflammatory cytokines tumor necrosis factor-α,IL-1β, and IL-6, and collagen-specific T cell responses were observed in mice that received IL-17-/- bone marrow. IL-17 blockade also inhibited effector T cell proliferation by reciprocally regulating the Treg/Th17ratio. IL-17 blockade prevented joint destruction in mice with CIA. These findings suggest that CIA with BMT is a viable method of immunological manipulation and that IL-17 deficiency suppresses severe joint destruction and inflammation in CIA mice. There may be clinical benefits in blocking IL-17 and BMT in the treatment of rheumatoid arthritis.
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참고문헌 (23)
참고문헌 신청
Bettelli E / 2007 / T(H)-17 cells in the circle of immunity and autoimmunity / Nat Immunol 8 : 345 ~ 350
Bluestone JA / 2005 / Regulatory T-cell therapy: is it ready for the clinic? / Nat Rev Immunol 5 : 343 ~ 349
Camps M / 2005 / Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis / Nat Med 11 : 936 ~ 943
Chabaud M / 1999 / Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium / Arthritis Rheum 42 : 963 ~ 970
Cho ML / 2006 / STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mi
Bluestone JA / 2005 / Regulatory T-cell therapy: is it ready for the clinic? / Nat Rev Immunol 5 : 343 ~ 349
Camps M / 2005 / Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis / Nat Med 11 : 936 ~ 943
Chabaud M / 1999 / Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium / Arthritis Rheum 42 : 963 ~ 970
Cho ML / 2006 / STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mi
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