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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 665 - 673 (9page)
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초록· 키워드
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This study aimed to determine whether taurine supplementation improves metabolic disturbances and diabetic complications in an animal model for type 2diabetes. We investigated whether taurine has therapeutic effects on glucose metabolism, lipid metabolism,and diabetic complications in Otsuka Long-Evans Tokushima fatty (OLETF) rats with long-term duration of diabetes. Fourteen 50-week-old OLETF rats with chronic diabetes were fed a diet supplemented with taurine (2%) or a non-supplemented control diet for 12 weeks. Taurine reduced blood glucose levels over 12 weeks, and improved OGTT outcomes at 6 weeks after taurine supplementation, in OLETF rats. Taurine significantly reduced insulin resistance but did not improve β-cell function or islet mass. After 12 weeks, taurine significantly decreased serum levels of lipids such as triglyceride, cholesterol, high density lipoprotein cholesterol, and low density lipoprotein cholesterol. Taurine significantly reduced serum leptin, but not adiponectin levels. However,taurine had no therapeutic effect on damaged tissues.
Taurine ameliorated hyperglycemia and dyslipidemia,at least in part, by improving insulin sensitivity and leptin modulation in OLETF rats with long-term diabetes. Additional study is needed to investigate whether taurine has the same beneficial effects in human diabetic patients.
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참고문헌 (23)
참고문헌 신청
Bieri J / 1977 / Report of the American Institute of Nurtition ad hoc Committee on Standards for Nutritional Studies / J Nutr 107 : 1340 ~ 1348
Brons C / 2004 / Effect of taurine treatment on insulin secretion and action, and on serum lipid levels in overweight men with a genetic predisposition for type II diabetes m
Bruns H / 2011 / Glycine and taurine equally prevent fatty livers from Kupffer cell-dependent injury: an in vivo microscopy study / Microcirculation 18 : 205 ~ 213
Chen X / 2009 / Taurine supplementation prevents ethanol-induced decrease in serum adiponectin and reduces hepatic steatosis in rats / Hepatology 49 : 1554 ~ 1562
Das J / 2012 / Taurine exerts hypoglycemic effect in alloxan-induced diabetic rats, improves insulin-mediated glucose transport signaling pathway in heart and ameliorates car
Brons C / 2004 / Effect of taurine treatment on insulin secretion and action, and on serum lipid levels in overweight men with a genetic predisposition for type II diabetes m
Bruns H / 2011 / Glycine and taurine equally prevent fatty livers from Kupffer cell-dependent injury: an in vivo microscopy study / Microcirculation 18 : 205 ~ 213
Chen X / 2009 / Taurine supplementation prevents ethanol-induced decrease in serum adiponectin and reduces hepatic steatosis in rats / Hepatology 49 : 1554 ~ 1562
Das J / 2012 / Taurine exerts hypoglycemic effect in alloxan-induced diabetic rats, improves insulin-mediated glucose transport signaling pathway in heart and ameliorates car
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