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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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- 학술저널
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- 2013.1
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Hair cells at the base of the cochlea appear to be more susceptible to damage by the aminoglycoside gentamicin than those at the apex. However, the mechanism of base-to-apex gradient ototoxicity by gentamicin remains to be elucidated. We report here that gentamicin caused rodent cochlear hair cell damages in a time- and dose-dependent manner. Hair cells at the basal turn were more vulnerable to gentamicin than those at the apical turn. Gentamicin-conjugated Texas Red (GTTR) uptake was predominant in basal turn hair cells in neonatal rats. Transient receptor potential vanilloid 1 (TRPV1) and 4 (TRPV4) expression was confirmed in the cuticular plate, stereocilia and hair cell body of inner hair cells and outer hair cells. The involvement of TRPV1 and TRPV4 in gentamicin trafficking of hair cells was confirmed by exogenous calcium treatment and TRPV inhibitors,including gadolinium and ruthenium red, which resulted in markedly inhibited GTTR uptake and gentamicin-induced hair cell damage in rodent and zebrafish ototoxic model systems. These results indicate that the cytotoxic vulnerability of cochlear hair cells in the basal turn to gentamicin may depend on effective uptake of the drug, which was, in part, mediated by the TRPV1and TRPV4 proteins.
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참고문헌 (26)
참고문헌 신청
Forge A / 1993 / Freeze fracture analysis of apical membranes in cochlear cultures: differences between basal and apical-coil outer hair cells and effects of neomycin / J Neu
Fritzsch B / 1988 / The amphibian octavo-lateralis system and its regressive and progressive evolution / Acta Biol Hung 39 : 305 ~ 322
Gompel N / 2001 / Pattern formation in the lateral line of zebrafish / Mech Dev 105 : 69 ~ 77
Gong X / 2002 / Molecular determinants of Au(CN)(2)(-) binding and permeability within the cystic fibrosis transmembrane conductance regulator Cl(-) channel pore / J Physiol
Harris JA / 2003 / Neomycin-induced hair cell death and rapid regeneration in the lateral line of zebrafish (Danio rerio) / J Assoc Res Otolaryngol 4 : 219 ~ 234
Fritzsch B / 1988 / The amphibian octavo-lateralis system and its regressive and progressive evolution / Acta Biol Hung 39 : 305 ~ 322
Gompel N / 2001 / Pattern formation in the lateral line of zebrafish / Mech Dev 105 : 69 ~ 77
Gong X / 2002 / Molecular determinants of Au(CN)(2)(-) binding and permeability within the cystic fibrosis transmembrane conductance regulator Cl(-) channel pore / J Physiol
Harris JA / 2003 / Neomycin-induced hair cell death and rapid regeneration in the lateral line of zebrafish (Danio rerio) / J Assoc Res Otolaryngol 4 : 219 ~ 234
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