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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
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- 1 - 10 (10page)
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Pancreatic ductal adenocarcinoma (PDAC) is among the most devastating human malignancies. The poor clinical outcome in PDAC is partly attributed to a growth-permissive tumor microenvironment. In the PDAC microenvironment, the stroma is characterized by the development of extensive fibrosis, with stromal components outnumbering pancreatic cancer cells. Each of the components within the stroma has a distinct role in conferring chemoresistance to PDAC, and intrinsic chemoresistance has further worsened this pessimistic prognosis. The nucleoside analog gemcitabine (GEM) is usually the recommended first-line chemotherapeutic agent for PDAC patients and is given alone or in combination with other agents. The mechanisms of intrinsic resistance to GEM are an active area of ongoing research. This review highlights the important role the complex structure of stroma in PDAC plays in the intrinsic resistance to GEM and discusses whether antistroma therapy improves the efficacy of GEM. The addition of antistroma therapy combined with GEM is expected to be a novel therapeutic strategy with significant survival benefits for PDAC patients.
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참고문헌 (25)
참고문헌 신청
Amit M / 2013 / Macrophages increase the resistance of pancreatic adenocarcinoma cells to gemcitabine by upregulating cytidine deaminase / Oncoimmunology 2 : e27231 ~
Apte MV / 2004 / Desmoplastic reaction in pancreatic cancer : role of pancreatic stellate cells / Pancreas 29 : 179 ~ 187
Binenbaum Y / 2015 / Gemcitabine resistance in pancreatic ductal adenocarcinoma / Drug Resist Updat 23 : 55 ~ 68
Burris HA 3rd / 1997 / Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer : a randomized trial /
Chu GC / 2007 / Stromal biology of pancreatic cancer / J Cell Biochem 101 : 887 ~ 907
Apte MV / 2004 / Desmoplastic reaction in pancreatic cancer : role of pancreatic stellate cells / Pancreas 29 : 179 ~ 187
Binenbaum Y / 2015 / Gemcitabine resistance in pancreatic ductal adenocarcinoma / Drug Resist Updat 23 : 55 ~ 68
Burris HA 3rd / 1997 / Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer : a randomized trial /
Chu GC / 2007 / Stromal biology of pancreatic cancer / J Cell Biochem 101 : 887 ~ 907
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