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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 358 - 366 (9page)
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초록· 키워드
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The rearrangement of the actin cytoskeleton has
been shown to play a critical role in the development
of transformation and m alignant phenotype
of cancer cells. Rho family GTPases regulate
the arrangement of the actin cytoskeleton.
By wound-healing assay, we have found that
NIH 3T3 fibroblast cells move towards the woundgaps
by extending filopodial and lamellipdial
structures at the leading edge of the moving
cells. We have inactivated the function of Rho
GTPases of v-Ras transformed NIH 3T3 cells by
overexpressing Rho GTPase-activating (RhoGAP)
domain of RhoGAP of p190. W e have observed
that inactivation of Rho, Rac and Cdc42 GTPases
by overexpressing RHG causes inhibition
of: (i) polymerization of actin to form filaments,
(ii) formation of lamellipodia, filopodia and stress
fibres, (iii) cell m otility, (iv) cell spreading and
(v) cell-to-cell adhesions. These results further
strengthen the current knowledge on the role of
Rho, Rac and Cdc42 GTPases in the regulation
of the rearrangement of actin cytoskeleton. Our
results, for the first time, demonstrate that
RhoGAP domain of RhoGAP could be used to
study the m olecular mechanism of Ras-mediated
signalling in growth, differentiation and carcinogenesis.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
/ / Function and regulation of Ras : 851 ~ 91
/ / Molecular cloning of cDNAs encoding the GAP-associatedprotein p190 implications for a signaling pathway from rasto the nucleus : 539 ~ 49
/ / The small GTP-binding protein rhoregulates the assembly of focal adhesions and actin stressfibers in response to growth factors : 389 ~ 99
/ 1995 / Activation of Rac1 RhoA and mitogen-activated proteinkinases is required for Ras transformation : 6443 ~ 53
/ 1995 / Rac and Cdc42 GTPases : 456 ~ 9
/ / Molecular cloning of cDNAs encoding the GAP-associatedprotein p190 implications for a signaling pathway from rasto the nucleus : 539 ~ 49
/ / The small GTP-binding protein rhoregulates the assembly of focal adhesions and actin stressfibers in response to growth factors : 389 ~ 99
/ 1995 / Activation of Rac1 RhoA and mitogen-activated proteinkinases is required for Ras transformation : 6443 ~ 53
/ 1995 / Rac and Cdc42 GTPases : 456 ~ 9
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