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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 419 - 426 (8page)
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초록· 키워드
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Radiation is the most useful treatment modality for cancer patients. It initiates a series of signal cascades such as DNA damage response (DDR) signaling for repairing damaged DNA, arresting the cell cycle, and inducing cell death. Until now, few genes have been found to be regulated by radiation, which explains the molecular mechanisms of cellular responses to radiation.
Although the transcriptional changes caused by radiation have been widely investigated, little is known about the direct evidence for the transcriptional control of DDR-related genes. Here, we examined the radiosensitivity of two non-small cell lung cancer cell lines (H460 and H1299), which have different p53 status. We monitored the time-dependent changes of 24 DDR-related gene expressions via microarray analysis. Based on the basal expression levels and temporal patterns,we further classified 24 DDR-related genes into four subgroups. Then, we also addressed the protein levels of several DDR-related genes such as TopBP1, Chk1and Chk2, confirming the results of microarray analysis. Together, these results indicate that the expression patterns of DDR-related genes are associated with radiosensitivity and with the p53 statuses of H460and H1299, which adds to the understanding of the complex biological responses to radiation.
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참고문헌 (23)
참고문헌 신청
Amundson SA / 1999 / Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses / Oncogene 18 : 3666 ~ 3672
Bartek J / 2003 / Chk1 and Chk2 kinases in checkpoint control and cancer / Cancer Cell 3 : 421 ~ 429
Bartkova J / 2006 / Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints / Nature 444 : 633 ~ 637
Bartkova J / 2007 / DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours
Bartkova J / 2010 / Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas / Oncogene 29 : 5095 ~ 51
Bartek J / 2003 / Chk1 and Chk2 kinases in checkpoint control and cancer / Cancer Cell 3 : 421 ~ 429
Bartkova J / 2006 / Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints / Nature 444 : 633 ~ 637
Bartkova J / 2007 / DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours
Bartkova J / 2010 / Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas / Oncogene 29 : 5095 ~ 51
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