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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 733 - 739 (7page)
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초록· 키워드
오류제보하기
KR-31543, (2S, 3R, 4S)-6-amino-4-[N-(4-chlorophenyl)-N-(2-methyl-2H-tetrazol-5-ylmethyl) amino]-3,4-dihydro-2-dimethyoxymethyl-3-hydroxy-2-methyl-2H-1-benz opyran is a new neuroprotective agent for ischemiareperfusion damage. It has also been reported that KR-31543 has protective effects on lipid peroxidation and H2O2-induced reactive oxygen species production.
In this study, we investigated the anti-inflammatory and anti-atherogenic properties of KR-31543. We observed that KR-31543 treatment reduced the production of MCP-1, IL-8, and VCAM-1 in HUVECs,and of MCP-1 and IL-6 in THP-1 human monocytes. We also examined the effect of KR-31543 on monocytes migration in vitro. KR-31543 treatment effectively reduced the migration of THP-1 human monocytes to the HUVEC monolayer in a dose-dependent manner.
We next examined the effects of this compound on atherogenesis in LDL receptor deficient (Ldlr -/-) mice.
After 10 weeks of western diet, the formation of atherosclerotic lesion in aorta was reduced in the KR-31543-treated group compared to the control group. The accumulation of macrophages in lesion was also reduced in KR-31543 treated group. However,the plasma levels of total cholesterol, HDL, LDL, and triglyceride were not affected by KR-31543 treatment.
Taken together, these results show that KR-31543 has anti-inflammatory properties on human monocytes and endothelial cells, and inhibits fatty streak lesion formation in mouse model of atherosclerosis, suggesting the potential of KR-31543 for the treatment for atherosclerosis.
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참고문헌 (24)
참고문헌 신청
Carr AC / 2000 / Potential antiatherogenic mechanisms of ascorbate (vitamin C) and alpha-tocopherol (vitamin E) / Circ Res 87 : 349 ~ 354
Che W / 2002 / Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-alphainduced c-Jun and NF-kappaB activation an
Choi JH / 2003 / Hematein inhibits atherosclerosis by inhibition of reactive oxygen generation and NF-kappaB-dependent inflammatory mediators in hyperlipidemic mice / J Cardi
Claise C / 1996 / Oxidized low-density lipoprotein induces the production of interleukin-8 by endothelial cells / FEBS Lett 398 : 223 ~ 227
Collins T / 2001 / NF-kappaB: pivotal mediator or innocent bystander in atherogenesis? / J Clin Invest 107 : 255 ~ 264
Che W / 2002 / Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-alphainduced c-Jun and NF-kappaB activation an
Choi JH / 2003 / Hematein inhibits atherosclerosis by inhibition of reactive oxygen generation and NF-kappaB-dependent inflammatory mediators in hyperlipidemic mice / J Cardi
Claise C / 1996 / Oxidized low-density lipoprotein induces the production of interleukin-8 by endothelial cells / FEBS Lett 398 : 223 ~ 227
Collins T / 2001 / NF-kappaB: pivotal mediator or innocent bystander in atherogenesis? / J Clin Invest 107 : 255 ~ 264
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